A series of 4-alkoxycarbonyl-1,5-diaryl-1,2,3-triazoles were synthesized regioselectively using click chemistry and evaluated at CB1 cannabinoid receptors. The n-propyl ester 11 (K(i)=4.6 nM) and phenyl ester 14 (K(i)=11 nM) exhibited the most potent affinity of the series.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2631625 | PMC |
| http://dx.doi.org/10.1016/j.bmcl.2008.11.110 | DOI Listing |
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