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Intraoperative circulation predict prolonged length of stay after head and neck free flap reconstruction: a retrospective study based on machine learning.
Front Oncol
January 2025
Department of Anesthesiology, Shenshan Medical Central, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Shanwei, China.
Background: Head and neck free flap reconstruction presents challenges in managing intraoperative circulation, potentially leading to prolonged length of stay (PLOS). Limited research exists on the associations between intraoperative circulation and PLOS given the difficulty of manual quantification of intraoperative circulation time-series data. Therefore, this study aimed to quantify intraoperative circulation data and investigate its association with PLOS after free flap reconstruction utilizing machine learning algorithms.
View Article and Find Full Text PDFQnox index for quantification of intraoperative nociception and analgesia: a prospective single-centre validation study.
Br J Anaesth
January 2025
Department of Anaesthesiology, Peking University First Hospital, Beijing, China; Outcomes Research Consortium, Cleveland, OH, USA.
Background: The Qnox index is a novel monitor to quantify intraoperative nociception based on an electroencephalographic algorithm. We evaluated the ability of the Qnox index to discriminate noxious from non-noxious stimuli, respond to stimuli, and discriminate different levels of analgesia in patients under propofol anaesthesia with neuromuscular block.
Methods: Qnox was compared with heart rate and mean arterial pressure with five designated stimuli: tetanic stimulations without (tetanic 1) and with sufentanil (tetanic 2), skin incision, tracheal intubation, and a non-noxious period.
Nanopore-based random genomic sampling for intraoperative molecular diagnosis.
Genome Med
January 2025
Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH, 03756, USA.
Background: Central nervous system tumors are among the most lethal types of cancer. A critical factor for tailored neurosurgical resection strategies depends on specific tumor types. However, it is uncommon to have a preoperative tumor diagnosis, and intraoperative morphology-based diagnosis remains challenging.
View Article and Find Full Text PDFPre-surgical Embolization of Meningiomas: Analysis of Safety and Efficacy in a Mexican National Center And Proposal for a Classification of Preoperative Embolization of Meningiomas Based on Embolic Agent Penetration.
World Neurosurg
January 2025
Neurosurgical Fellow, Stroke Team México, American Association of Neurological Surgeons Student Chapter, Universidad Autónoma del Estado de Hidalgo, Hidalgo, 42160, México.
Introduction: Meningiomas are the most common primary central nervous system tumors, often requiring surgical resection. Presurgical embolization (PSE) is used to reduce intraoperative bleeding, although its effectiveness varies. This study evaluates the safety and efficacy of PSE using ethyl-vinyl alcohol (EVOH) in meningioma surgeries.
View Article and Find Full Text PDFIn Situ Light-Source Delivery During 5-Aminulevulinic Acid-Guided High-Grade Glioma Resection: Spatial, Functional and Oncological Informed Surgery.
Biomedicines
November 2024
Department of Neurosurgery, King's College Hospital NHS Foundation Trust, London SE5 9RS, UK.
Background/objectives: 5-aminulevulinic acid (5-ALA)-guided surgery for high-grade gliomas remains a challenge in neuro-oncological surgery. Inconsistent fluorescence visualisation, subjective quantification and false negatives due to blood, haemostatic agents or optical impediments from the external light source are some of the limitations of the present technology.
Methods: The preliminary results from this single-centre retrospective study are presented from the first 35 patients operated upon with the novel Nico Myriad Spectra System©.
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