AI Article Synopsis
- Mannose binding lectin (MBL) is a key protein that helps the immune system fight off fungal infections, especially against species like C. parapsilosis and C. albicans.
- The study found that MBL binds strongly to these fungi, enhancing the immune response by promoting the deposition of complement proteins and increasing their uptake by certain immune cells.
- Overall, MBL is vital for antifungal immunity, as it significantly boosts the ability of polymorphonuclear cells to recognize and eliminate yeast pathogens.
Article Abstract
Background: Mannose binding lectin (MBL) is an important host defence protein against opportunistic fungal pathogens. This carbohydrate-binding protein, an opsonin and lectin pathway activator, binds through multiple lectin domains to the repeating sugar arrays displayed on the surface of a wide range of clinically relevant microbial species. We investigated the contribution of MBL to antifungal innate immunity towards C. parapsilosis in vitro.
Results: High avidity binding was observed between MBL and C. albicans and C. parapsilosis. Addition of MBL to MBL deficient serum increased the deposition of C4 and C3b and enhanced the uptake of C. albicans, C. parapsilosis and acapsular C. neoformans by polymorphonuclear cells (PMNs). Compared to other microorganisms, such as Escherichia coli, Staphylococcus aureus and Cryptococcus neoformans, C. parapsilosis and Candida albicans were potent activators of the lectin pathway.
Conclusion: Our results suggest that MBL plays a crucial role in the innate immunity against infections caused by yeast by increasing uptake by PMN.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2627907 | PMC |
| http://dx.doi.org/10.1186/1471-2180-8-229 | DOI Listing |
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