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Human epidermal growth factor receptor 2 (HER2, also known as ERBB2) signaling promotes cell growth and differentiation, and is overexpressed in several tumor types, including breast, gastric and colorectal cancer. HER2-targeted therapies have shown clinical activity against these tumor types, resulting in regulatory approvals. However, the efficacy of HER2 therapies in tumors with HER2 mutations has not been widely investigated.
View Article and Find Full Text PDFDevelopment of Public Health Center-Based Culturally Tailored Hypertension Self-Care Intervention Among Adults in Rural Ghana.
Public Health Nurs
January 2025
Department of Medical Humanities and Social Sciences, College of Medicine, Yonsei University, Seoul, South Korea.
Objectives: Develop a primary health care-based nurse-led culturally tailored hypertension self-care intervention for rural residents.
Design: The culturally tailored hypertension self-care intervention was developed using a six-step intervention mapping approach that involved: needs assessment using literature review and interviews; setting program goals using integrated thematic synthesis method; selecting intervention modules through the process dimension of the self-care theory of chronic illness; producing program components and materials by developing intervention modules using the motivational interviewing and behavior change techniques; planning program adoption by encouraging sustainable behavior; and evaluation using the education content validity index in health and the intervention acceptability, appropriateness, and feasibility scale.
Measurements: Education content validity index in health and the intervention acceptability, appropriateness, and feasibility scale.
Exploring health influences and the moderating role of authentic leadership in workplace bullying: A cross-sectional study among hospital nurses.
Int Nurs Rev
March 2025
Department of Foreign Languages, Fooyin University, Kaohsiung City, Taiwan.
Aim: This study explored the relationship between workplace bullying, authentic leadership, workplace friendship and nurses' health conditions and identified the predictors of nurses' health. It also explored whether authentic leadership moderated the impact of workplace bullying on their health.
Methods: This study used a cross-sectional and correlational design following the STROBE guidelines.
Experiences and perceptions of respectful maternity care among mothers during childbirth in health facilities of Eastern province of Rwanda: An appreciative inquiry.
PLoS One
January 2025
School of Nursing and Midwifery, University of Rwanda, Kigali, Rwanda.
Introduction: The World Health Organization (WHO) has emphasized the importance of ensuring respectful and dignified childbirth experiences. However, many countries, including Rwanda, have documented negative experiences during childbirth. Identifying best practices can help uncover sustainable solutions for resource-limited settings rather than focusing solely on the challenges and negative aspects.
View Article and Find Full Text PDFComplementary and Integrative Health Use in Binge Eating Disorder: A Cross-Sectional Mixed-Methods Study of Binge Eating Disorder Experts' Perspectives.
Int J Nurs Health Care Res (Lisle)
October 2024
Helfgott Research Institute, National University of Natural Medicine, Portland, OR, USA.
Introduction: Binge Eating Disorder (BED) has high lifetime prevalence rates, low treatment success rates, and high rates of treatment dissatisfaction, early discontinuation of care, and recurrence. Complementary and integrative health (CIH) interventions (non-mainstream practices used with conventional approaches for whole-person treatment) hold potential to overcome many treatment barriers and improve BED treatment outcomes. Some CIH interventions have empirical support for use in eating disorders.
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