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Asiatic acid methyl ester, a new asiaticoside derivative, induces osteogenic differentiation of hPDLCs.
Arch Oral Biol
January 2025
Pharmaceutical Sciences and Technology Program, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand; Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand; Center of Excellent in Natural Products and Nanoparticles (NP2), Chulalongkorn University, Bangkok, Thailand.
Objective: Asiaticoside has the capacity to induce osteogenic differentiation of human periodontal ligament cells (hPDLCs) through Wnt (Wingless-related integration site) signaling. A modified chemical structure (by removing glycoside side chain), referred to as asiatic acid methyl ester (AA1), has been constructed and evaluated for its capacity to induce osteogenic differentiation.
Design: hPDLCs viability was determined by MTT assay.
The effects of synbiotic supplementation along with non-surgical periodontal therapy in improving the metabolic status and inflammatory markers in type 2 diabetes mellitus patients with periodontal disease: A double-blind randomized clinical trial.
J Educ Health Promot
November 2024
Department of Biostatistics, School of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Background: Diabetes mellitus and periodontitis are two common chronic diseases with bidirectional relationship. Considering the role of oxidative stress in the pathogenesis of these two diseases, the use of nutritional supplements with antioxidant properties can be useful. The purpose of this study was to determine the effectiveness of daily synbiotic supplement in the management of patients with type 2 diabetes mellitus (T2DM) and periodontal disease (PD) under non-surgical periodontal therapy (NSPT).
View Article and Find Full Text PDFImpact of crack cocaine on salivary nucleic acids, enzymes, esters, and lipids: A fourier-transform infrared spectroscopy study.
Heliyon
January 2025
Universidade Estadual Paulista (Unesp), Instituto de Ciência e Tecnologia, Câmpus de São José dos Campos, São Paulo, Brazil.
Objective: This study aims to analyze saliva composition in crack users using vibrational spectroscopy.
Material And Methods: A total of 90 participants were meticulously selected and divided into three groups, each comprising 30 individuals. All participants met the criterion of having no observable clinical changes in the oral mucosa.
Mitochondrial Dysfunction in Diabetic Periodontitis: Mechanisms and Therapeutic Potential.
J Inflamm Res
January 2025
Anhui Province Engineering Research Center for Dental Materials and Application, School of Stomatology, Wannan Medical College, Wuhu, 241002, People's Republic of China.
Diabetic periodontitis is a common oral complication of diabetes characterized by progressive destruction of periodontal tissues. Recent evidence suggests that mitochondrial dysfunction plays a crucial role in the pathogenesis and progression of this condition. This review aims to systematically summarize the role and potential mechanisms of mitochondrial dysfunction in diabetic periodontitis.
View Article and Find Full Text PDF[Einfluss von Gender auf Parodontitis: Prävention, Prävalenz und Ätiologie in einer narrativen Übersicht].
Swiss Dent J
January 2025
Klinik für Zahnerhaltung und Präventivzahnmedizin.
Periodontitis leads to a destruction of the tooth-supporting apparatus, which untreated may end up in tooth-loss. Key factor in the pathogenesis of periodontitis is the host immune response, genetic predisposition, and lifestyle factors (such as smoking, stress, and diabetes), all of which influence disease severity. Periodontitis is more common in men than women, this fact may point out that gender may have an influence on periodontitis.
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