AI Article Synopsis
- The study demonstrates the effectiveness of air-stable palladium complexes in catalyzing the one-pot asymmetric reductive amination of carbonyl compounds.
- These complexes include [(R)-BINAP]PdBr2, [(S)-BINAP]PdBr2, [(R)-Tol-BINAP]PdBr2, and [(S,S)-CHIRAPHOS]PdBr2.
- The process yields chiral amines with high yields and excellent enantioselectivity, achieving values close to 99% ee.
Article Abstract
The application of air stable preformed [(R)-BINAP]PdBr2, [(S)-BINAP]PdBr2, [(R)-Tol-BINAP]PdBr2, and [(S,S)-CHIRAPHOS]PdBr2 complexes in the one-pot asymmetric reductive amination of various carbonyl compounds, leading to chiral amines in very good yields with high enantioselectivities (<99% ee), is reported.
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| http://dx.doi.org/10.1021/ol802336m | DOI Listing |
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