Purpose: This study was designed to determine the effects of prior exercise on energy supply and performance in a laboratory-based 4000-m time trial.
Methods: After one familiarization trial, eight well-trained cyclists (mean +/- SD; age = 30 +/- 8 yr, body mass = 78.7 +/- 8.6 kg, stature = 181 +/- 5 cm, .VO2 peak = 63.7 +/- 6.7 mL.kg.(-1)min(-1), peak power output (PPO) = 366 +/- 39 W) performed three 4000-m laboratory-based cycling time trials each preceded by one of three prior exercise regimens in randomized order: no prior exercise (control), prior heavy exercise, and self-selected prior exercise.
Results: Cyclists adopted a wide range of self-selected prior exercise regimens: duration ranged = 11-80 min, intensity = 48-120% PPO, and recovery = 2-11 min. Relative to control, pre-time-trial blood lactate was raised by 2.5 +/- 1.9 and 1.4 +/- 1.5 mmol.L(-1) after prior heavy and self-selected exercise, respectively. The 4000 m was completed 2.0 +/- 2.3% and 2.2 +/- 1.9% faster after prior heavy and self-selected exercise regimens, respectively, and mean power output was 5.4 +/- 3.6% and 6.0 +/- 5.8% higher, respectively. The overall aerobic contribution (.VO2) and oxygen deficit were not different between conditions (approximately 323 +/- 23 and approximately 64 +/- 22 mL.kg,(-1) respectively), although .VO2 was higher (P < 0.05) in the prior heavy (by 2.1-5.8 mL.kg(-1).min(-1)) and self-selected (2.5-4.3 mL.kg(-1).min(-1)) regimens compared with the control throughout the first half of the time trial.
Conclusion: Very high intensity cycling performance was improved after both self-selected and prior heavy exercise. Such priming increased the early aerobic contribution but did not change overall aerobic contribution or oxygen deficit. Thus, athletes seem to manage their energy potential to exploit the available anaerobic capacity, independent of the aerobic contribution. Athletes are advised to perform a bout of heavy exercise as part of their prior exercise regimen.
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Gastro Hep Adv
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Division of Gastroenterology and Hepatology, Duke University, Durham, North Carolina.
Background And Aims: Alcohol-related liver disease is a leading cause of liver transplantation (LT) in the United States; however, alcohol relapse remains a risk, and real-world assessment of relapse prediction scores is lacking. The primary aim of this study was to assess risk factors for alcohol relapse and compare effectiveness of pre-existing risk scores (e.g.
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Pacific Northwest National Laboratory, 902 Battelle Boulevard, Richland, Washington 99354, United States.
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Servicio de Hematología, Hospital Universitario Vall d'Hebron, Barcelona, España.
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Methodology: The references obtained were classified according to the level of evidence and following the criteria established by the Agency for Health Research and Quality, and the recommendations were classified according to the criteria of the National Comprehensive Cancer Network (NCCN).
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NICM Health Research Institute, Western Sydney University, Sydney, Australia. Electronic address:
Study Objective: To explore menstrual cycle symptoms, information sources and menstrual health literacy in young women (aged 13-25) and those who menstruate in Aotearoa New Zealand.
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Department of Cardiology, Cardiac Arrhythmia Center, Affiliated Hospital of Nantong University, Nantong 226001, China. Electronic address:
Doxorubicin (DOX), a chemotherapeutic agent utilized in the management of cancer, provokes cardiotoxicity although effective remedy is lacking. Given that DOX provokes oxidative stress and cell death in cardiomyocytes, this study evaluated the possible involvement of cuproptosis, a newly identified form of cell death, in DOX-instigated cardiac remodeling and contractile dysfunction, alongside the impact of the heavy metal scavenger metallothionein (MT) on DOX cardiomyopathy. Cardiac-specific MT transgenic and wild-type (WT) mice were treated with DOX (5 mg/kg/wk.
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