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Cardiac resynchronization therapy via left bundle branch pacing in heart failure with complete left bundle branch block: is the defibrillator needed?
Front Cardiovasc Med
January 2025
Department of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Aims: This retrospective cohort study aimed to investigate the efficacy of dual-chamber left Bundle branch pacing (LBBP) as an alternative therapy for heart failure patients with complete left bundle branch block (CLBBB) and indications for defibrillator with cardiac resynchronization therapy (CRT-D).
Methods: 34 patients met inclusion criteria were enrolled in the study. These criteria included a left ventricular ejection fraction (LVEF) of lower than 35%, a New York Heart Association functional class of II-IV, CLBBB meeting Strauss's criteria, intraventricular dyssynchrony, and confirmed correction of CLBBB during LBBP.
Enhanced porphyrin-based hypoxia imaging by temporal oversampling of delayed fluorescence signal.
J Biomed Opt
February 2025
University of Wisconsin-Madison, Department of Medical Physics, Madison, Wisconsin, United States.
Significance: Protoporphyrin IX (PpIX) delayed fluorescence (DF) is inversely related to the oxygen present in tissues and has potential as a novel biomarker for surgical guidance and real-time tissue metabolism assessment. Despite the unique promise of this technique, its successful clinical translation is limited by the low intensity emitted.
Aim: We developed a systematic study of ways to increase the PpIX DF signal through acquisition sampling changes, allowing optimized imaging at video rates.
Adult onset wilms tumor.
Radiol Case Rep
March 2025
Department of Radiology, Massachusetts General Hospital, Boston MA.
Wilms tumor (WT) is the most common primary renal malignancy in the pediatric population and has very good overall survival with contemporary treatment protocols. In contrast, WT in adults is extremely rare and is associated with a poorer prognosis. The clinical presentation and imaging features of WT in adults are nonspecific and overlap with other more common forms of renal cancer, often leading to a delay in diagnosis.
View Article and Find Full Text PDFSerum starvation impacts rhinovirus spread from cell to cell.
Virology
January 2025
Wisconsin Institute for Discovery, Chemical and Biological Engineering, University of Wisconsin-Madison, 330 N. Orchard Street, Madison, WI, 53715, USA. Electronic address:
Single-cell studies of virus infection have found significant heterogeneity in virus and host gene expression as well as the kinetics of progeny particle release. However, such studies have yet to examine how the resulting virus descendants spread and infect nearby cells. We monitored reporter-gene expression from a recombinant rhinovirus in cell monolayers infected at low multiplicity of infection; we found that the second round of infection consistently exhibited a shorter delay in fluorescence signal appearance relative to the first round, indicating an acceleration in infection spread.
View Article and Find Full Text PDFUnderstanding retinal tau pathology through functional 2D and 3D iPSC-derived in vitro retinal models.
Acta Neuropathol Commun
January 2025
Department of Physiology and Pharmacology, Sapienza University of Rome, 00185, Rome, Italy.
The generation of retinal models from human induced pluripotent stem cells holds significant potential for advancing our understanding of retinal development, neurodegeneration, and the in vitro modeling of neurodegenerative disorders. The retina, as an accessible part of the central nervous system, offers a unique window into these processes, making it invaluable for both study and early diagnosis. This study investigates the impact of the Frontotemporal Dementia-linked IVS 10 + 16 MAPT mutation on retinal development and function using 2D and 3D retinal models derived from human induced pluripotent stem cells.
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