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Multitarget-Directed Ligands Hitting Serotonin Receptors: A Medicinal Chemistry Survey.
Pharmaceuticals (Basel)
September 2024
Department of Pharmacy-Drug Sciences, University of Bari Aldo Moro, Via Orabona, 4, 70125 Bari, Italy.
Serotonin (5-hydroxytryptamine, 5-HT) is a ubiquitous neurotransmitter in the human body. In the central nervous system, 5-HT affects sleep, pain, mood, appetite, and attention, while in the peripheral nervous system, 5-HT modulates peristalsis, mucus production, and blood vessel dilation. Fourteen membrane receptors mediate 5-HT activity.
View Article and Find Full Text PDFCase report: Anti-ARHGAP26 autoantibodies in atypical dementia with Lewy bodies.
Front Dement
August 2023
Department of Nuclear Medicine, University Medical Center Göttingen, Göttingen, Germany.
Background: Dementia with Lewy bodies (DLB) is the second most common type of neurodegenerative dementia. Here, we report a case of dementia associated with anti-Rho-GTPase-activating protein 26 (ARHGAP26) autoantibodies, which have never been previously linked to DLB.
Methods: We describe the case of a 78-year-old man who underwent cerebrospinal fluid (CSF) analysis, magnetic resonance imaging (MRI), F-fluorodesoxyglucose positron emission tomography (FDG-PET), and a detailed neuropsychological evaluation.
Physostigmine reversal of delirium from second generation antipsychotic exposure: a retrospective cohort study from a regional poison center.
Clin Toxicol (Phila)
July 2024
MN Regional Poison Center, Minneapolis, Minnesota, USA.
Introduction: Physostigmine is an effective antidote for antimuscarinic delirium. There is little evidence for its use to reverse delirium following second generation antipsychotic exposure. The purpose of this study is to describe the safety and effectiveness of physostigmine in reversing delirium from second generation antipsychotic exposure.
View Article and Find Full Text PDFAnalysis of events from sudden isolated dysarthria to diagnosis of myasthenic crisis: myasthenia gravis mimicking acute lacunar stroke-a case report.
J Med Case Rep
July 2024
Epsom General Hospital, Dorking Rd, Epsom, KT18 7EG, UK.
Background: Myasthenic crisis (MC) is a life-threatening complication of myasthenia gravis (MG), necessitating ventilation. Achieving a safe and timely diagnosis of myasthenic crisis with atypical, isolated presentation is a considerable challenge particularly in elderly patients, where myasthenia gravis can present with isolated dysarthria in rare instances, giving a clinical impression of lacunar stroke.
Case Presentation: We present a compelling case of a 73-year-old Caucasian female presenting with abrupt onset of isolated dysarthria.
A Male Patient Presents With Isolated Abducens Nerve Palsy: An Atypical Presentation of Ocular Myasthenia Gravis.
Cureus
April 2024
Internal Medicine, Bond Clinic, P.A., Winter Haven, USA.
Myasthenia gravis is an autoimmune disease of the neuromuscular junction caused by autoantibodies directed against the acetylcholine receptors. It presents with skeletal muscle weakness, often initially presenting with ocular symptoms such as ptosis and diplopia. When myasthenia gravis is isolated to only ocular symptoms, it is referred to as ocular myasthenia gravis (OMG).
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