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New complex cell junctions in and around the intervertebral discs discovered using autoantibodies from patients affected by endemic pemphigus foliaceus in El Bagre, Colombia, South America.
Int J Dermatol
September 2024
Georgia Dermatopathology Associates, Atlanta, GA, USA.
Article Synopsis
- The study investigates a new variant of endemic pemphigus foliaceus in El Bagre, Colombia, which causes back pain in patients and focuses on the reactivity of their autoantibodies to intervertebral disks (IVDs).
- Researchers used various diagnostic methods, including questionnaires and advanced microscopy, to analyze patient sera and compare them with control sera from healthy individuals in the area.
- Results showed that patients' sera contained antibodies targeting newly identified cell junctions in the IVDs and surrounding structures, suggesting a deeper understanding of spinal diseases and potential implications for treatment.
Degradation of p0071 and p120-catenin during adherens junction disassembly by .
Front Cell Infect Microbiol
November 2023
Department of Bacteriology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
disseminates hematogenously to reach the target organs by disrupting epithelial adherens junctions (AJs), thus causing leptospirosis, which is a globally neglected zoonotic disease. induces E-cadherin (E-cad) endocytosis and cytoskeletal rearrangement during AJ disassembly, but the detailed mechanism remains unknown. Elucidation of AJ disassembly mechanisms will guide new approaches to developing vaccines and diagnostic methods.
View Article and Find Full Text PDFp120-catenin subfamily members have distinct as well as shared effects on dendrite morphology during neuron development .
Front Cell Neurosci
April 2023
Department of Genetics, University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Dendritic arborization is essential for proper neuronal connectivity and function. Conversely, abnormal dendrite morphology is associated with several neurological pathologies like Alzheimer's disease and schizophrenia. Among major intrinsic mechanisms that determine the extent of the dendritic arbor is cytoskeletal remodeling.
View Article and Find Full Text PDFPatterns of Antinuclear Antibodies in a New Variant of Endemic Pemphigus in El Bagre, Colombia, Colocalizing with Antigens against MIZAP, ARVCF, p0071, and Desmoplakins I and II.
J Appl Lab Med
October 2022
Georgia Dermatopathology Associates, Atlanta, GA, USA.
Article Synopsis
- A new variant of pemphigus foliaceus, named El Bagre-EPF, exhibits a distinctive pattern of antinuclear antibodies (ANAs) that was studied in 57 patients compared to 57 control subjects.
- The research revealed that 24% of El Bagre-EPF patients showed a unique ANA pattern, characterized by specific nuclear staining, which was statistically significantly different from the control group.
- This new ANA pattern was linked with certain proteins (MIZAP, ARVCF, p0071, and desmoplakins I-II) and also showed that 14% of patients exhibited classic homogeneous ANA patterns related to other specific autoantibodies.
Armc8 is an evolutionarily conserved armadillo protein involved in cell-cell adhesion complexes through multiple molecular interactions.
Biosci Rep
August 2019
Department of Basic Medical Sciences, Ghent University, Ghent, Belgium
Armadillo-repeat-containing protein 8 (Armc8) belongs to the family of armadillo-repeat containing proteins, which have been found to be involved in diverse cellular functions including cell-cell contacts and intracellular signaling. By comparative analyses of armadillo repeat protein structures and genomes from various premetazoan and metazoan species, we identified orthologs of human Armc8 and analyzed in detail the evolutionary relationship of genes and their encoded proteins. Armc8 is a highly ancestral armadillo protein although not present in yeast.
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