We present a functional MRI experiment investigating the neural basis of feature-based attention in humans using the Stroop task. Cortical areas specifically involved in color processing and word reading were first identified in individual participants using independent tests. These areas were then probed during the Stroop task (in which participants must selectively attend to the font color of a word while ignoring the word itself). We found that activation in functionally defined color areas increased during the task relative to a neutral color-naming task while activation in functionally defined word areas decreased. These results are consistent with a biased competition model of feature-based attention in which the processing of attended features is enhanced and the processing of ignored features is suppressed.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659668 | PMC |
http://dx.doi.org/10.1523/JNEUROSCI.1026-08.2008 | DOI Listing |
Alzheimers Dement
December 2024
Università di Modena e Reggio Emilia, Modena, Italy.
Background: The effect of amyloid-b brain deposition on cognition is still debated, since it has been shown that its accumulation begins almost 15 years before cognitive symptoms' onset, then reaches a plateau while cognition continues to decline. We studied if there is a parallel between amyloid-b deposition and cognitive performances in young-onset Mild Cognitive Impairment (MCI) patients, and if it is associated to symptoms' duration.
Method: Subjects with a diagnosis of MCI and symptoms' onset ≤ 65 years underwent neuropsychological assessment, Magnetic Resonance Imaging, and (F)Flutemetamol-PET (amy-PET).
Alzheimers Dement
December 2024
University of Minnesota School of Medicine, Minneapolis, MN, USA.
Background: Traditional cognitive and daily functioning measures that utilize episodic assessment schedules are less sensitive to subtle within-person change in those at risk for Alzheimer's disease (AD). This study aimed to evaluate whether longitudinal trajectories of high frequency cognitive assessments (HFA) and passively assessed higher order instrumental activities of daily living (IADLs) differ between those with intact cognition (CN, n = 59) and mild cognitive impairment (MCI, n = 45). An exploratory aim evaluated whether the use of person-specific distributions would detect differences in longitudinal trajectories not captured by traditional between-group analyses.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Background: Clinically meaningful cognitive impairment has typically been defined as a single impaired test score, but this approach is prone to false-positive errors. Examining two test scores at a lower threshold (i.e.
View Article and Find Full Text PDFBackground: Type 2 diabetes (T2D) and older age are well-known risk factors for dementia. Indeed, there is evidence that older adults not diagnosed, but at-risk for T2D can show early signs of cognitive decline, further exacerbated by excessive body weight or high blood glucose levels. Such a finding would have implications for early treatment strategies; however, the evidence is still sparse.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Neurobehavioral Systems, Inc, Berkeley, CA, USA.
Background: Semantic memory assessments are sensitive indicators of cognitive decline in pre-clinical Alzheimer's Disease (AD), with slowed reaction time and diminished accuracy serving as markers for amyloid accumulation. We introduce the Semantic Stroop Test-a brief (4.3 minute), automated semantic retrieval and executive function task included in the California Cognitive Assessment Battery (CCAB).
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!