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Lithium, Inflammation and Neuroinflammation with Emphasis on Bipolar Disorder-A Narrative Review.
Int J Mol Sci
December 2024
Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Zlotowski Center for Neuroscience and Zelman Center-The School of Brain Sciences and Cognition, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
This narrative review examines lithium's effects on immune function, inflammation and cell survival, particularly in bipolar disorder (BD) in in vitro studies, animal models and clinical studies. In vitro studies show that high lithium concentrations (5 mM, beyond the therapeutic window) reduce interleukin (IL)-1β production in monocytes and enhance T-lymphocyte resistance, suggesting a protective role against cell death. Lithium modulates oxidative stress in lipopolysaccharide (LPS)-activated macrophages by inhibiting nuclear factor (NF)-ƙB activity and reducing nitric oxide production.
View Article and Find Full Text PDFAlterations in Biomarkers Associated with Cardiovascular Health and Obesity with Short-Term Lifestyle Changes in Overweight Women: The Role of Exercise and Diet.
Medicina (Kaunas)
December 2024
Department of Human Sciences and Promotion of the Quality of Life, San Raffaele Rome Open University, 00166 Rome, Italy.
: In this study, the effects of an eight-week exercise and nutrition program on blood lipids, glucose, insulin, insulin resistance (HOMA-IR), leptin, ghrelin, irisin, malondialdehyde (MDA), and Growth Differentiation Factor 15 (GDF15) in overweight women were investigated. : A total of 48 women volunteers participated in this study. The participants were randomly divided into four groups: control (C), exercise (E), nutrition (N), exercise + nutrition (E + N).
View Article and Find Full Text PDFSpinal Regulation of Posture: Effects of Transcutaneous Spinal Cord and Affective Sound Stimulation.
Life (Basel)
November 2024
Pavlov Institute of Physiology, Russian Academy of Sciences, 6 Makarova Enb., 199034 St. Petersburg, Russia.
The combined effects of transcutaneous electrical stimulation (tES) of the spinal cord and affective sound stimulation on postural control were investigated to elucidate the involvement of spinal networks in the maintenance of vertical stability. Healthy volunteers (n = 27) underwent tES and sound stimulation separately and combined quasi-randomly. All participants were field-dependent; i.
View Article and Find Full Text PDFScouting as a Strategy in Support of Mental Health Development Through the Formation of Sense of Self-Efficacy.
Brain Sci
December 2024
Faculty of Human Sciences, University of Economics and Innovation, 20-209 Lublin, Poland.
Background: This research project examining the moderating role of the Scout Movement in supporting mental health through the shaping of personal competence is based on Bandura's conception of social development (social cognitive theory) in terms of generating a sense of general self-efficacy.
Methods: This research examined the moderating value of Scouting with regard to the connection between self-esteem and a sense of efficacy and styles of coping with stress in a group of 683 volunteers.
Results: The results suggest that Scouting is a moderator of the relationship between the intensity of an emotion-focused stress coping style and a sense of self-efficacy-being a Scout intensifies the blocking effect of self-esteem on emotions in stressful situations, which can positively influence emotion regulation.
Regulation of human Th9 cell differentiation by lipid modulators targeting PPAR-γ and acetyl-CoA-carboxylase 1.
Front Immunol
January 2025
Department of Pharmaceutical Sciences, Marshall University School of Pharmacy, Huntington, WV, United States.
CD4 T cell activation induces dramatic changes to cellular metabolism for supporting their growth and differentiation into effector subsets. While the cytokines IL-4, TGF-β and IL-21 promote differentiation into Th9 cells, metabolic factors regulating this process remain poorly understood. To assess the role of lipid metabolism in human Th9 cell differentiation, naïve CD4 T cells were purified from blood of healthy volunteers and cultured in the presence or absence of compounds targeting PPAR-γ, acetyl-CoA-carboxylase 1 (ACC1), and AMP-activated protein kinase (AMPK) for four days.
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