Background: The role of bone formation and bioresorption in an early stage after implantation of beta-tricalcium phosphate (beta-TCP) was investigated using scanning and transmission electron microscopy (SEM, TEM).
Methods: The ceramic beta-TCP cylinders were implanted into cavities drilled in the femoral condyles of eight NZW rabbits. Four of the rabbits were sacrificed at 2 weeks and four at 4 weeks after implantation, respectively. The femoral condyles were excised to prepare the specimens for SEM and TEM.
Results: SEM showed giant cells of more than 20 mum in diameter were observed on the surface of beta-TCP at 2 weeks after implantation. TEM demonstrated that collagen fibrils secreted from the monocytic cells invaded beta-TCP micropores at 2 weeks. Multinucleated giant cells (MNGCs) were in contact with the surface of beta-TCP at 2 weeks. Some of them had a ruffled border (RB) at the cell-substrate interface, characteristic of osteoclasts.
Conclusions: These findings suggest that cell-mediated disintegration by osteoclasts played a role in the bioresorption of beta-TCP at an early stage after implantation. In addition, the micropores of beta-TCP ceramic may provide an environment for collagen formation, leading to the deposition of apatite crystals. Therefore, the micropores facilitate bone ingrowth as well as ceramic resorption.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00776-008-1271-1 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Aims: ultrasound (US) diagnosis of enthesitis is burdened of low specificity, especially when it is performed in patients with psoriasis (PsO) but without clinical psoriatic arthritis (PsA), because of mechanical, dysmetabolic and age-related concurrent enthesopatic changes. We propose a novel US score to quantify the cortical-entheseal bone remodeling burden of several peripheral entheses, aiming to improve the specificity of US for PsA-related enthesitis, and to evaluate its diagnostic value in PsO patients with subsequent diagnosis of psoriatic arthritis (PsO/PsA).
Methods: clinical and US data of 119 consecutive patients with moderate/severe PsO and nonspecific musculoskeletal symptoms, were included in this retrospective study.
Dichotomitin promotes osteoblast differentiation and improves osteoporosis by inhibiting oxidative stress.
J Orthop Surg Res
January 2025
Research Institute of Orthopedics, The Affiliated Jiangnan Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
Objective: Osteoporosis is a systemic disease with high morbidity and significant adverse effects. Increasing evidence supports the close relationship between oxidative stress and osteoporosis, suggesting that treatment with antioxidants may be a viable approach. This study evaluated the antioxidant properties of dichotomitin (DH) and its potential protective effects against osteoporosis.
View Article and Find Full Text PDFHow do lesions affect limb lengthening in children with Ollier's disease?
BMC Musculoskelet Disord
January 2025
Department of Pediatric Orthopaedics, Children's Hospital of Fudan University, National Children's Medical Center, 399 Wanyuan Rd, Minhang District, Shanghai, 201102, China.
Purpose: Ollier's disease (multiple enchondromatosis) can cause severe lower limb length discrepancy and deformity in children. Osteotomy and limb lengthening with external fixation can correct the lower extremity deformity. There may be lesions in the osteotomy part (OP), and the internal fixation part of the external fixation(FP).
View Article and Find Full Text PDFVimentin Inhibits Neuronal Apoptosis After Spinal Cord Injury by Enhancing Autophagy.
CNS Neurosci Ther
January 2025
Dongguan Key Laboratory of Stem Cell and Regenerative Tissue Engineering, the First Dongguan Affiliated Hospital, School of Basic Medical Sciences, Guangdong Medical University, Dongguan, China.
Aims: Neuron death is caused primarily by apoptosis after spinal cord injury (SCI). Autophagy, as a cellular response, can maintain cellular homeostasis to reduce apoptosis. We aimed to investigate the effect and the mechanism of vimentin knockdown on autophagy and neural recovery after SCI.
View Article and Find Full Text PDFEffect of molecular weight and distribution of bovine bone gelatin on the cross-linking gelation induced by transglutaminase.
Int J Biol Macromol
January 2025
State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. Electronic address:
In this work, six bovine bone gelatin (type B) samples with varying molecular weight (MW) fractions, comprising α-chains, high- and low-MW fractions, were prepared using ethanol precipitation and pH adjustment. The influence of molecular weight distribution (MWD) on gelatin gel strength was examined, along with the effects of these different MW fractions on microbial transglutaminase (MTGase) cross-linking gelatin. The results showed that, without MTGase treatment, high-MW fractions acted as key fillers in the formation of gelatin gel networks, while α-chains and their aggregates played a central role.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!