AI Article Synopsis
- Islet grafts can greatly improve the condition of diabetes patients through beta-cell therapy.
- The shortage of islets for transplantation and immune system challenges complicate the treatment process.
- The study proposes a method to convert liver cells (hepatocytes) into beta-cells by introducing specific genes that promote beta-cell development.
Article Abstract
Islet grafts have demonstrated that patients with diabetes would benefit greatly by beta-cell therapy. However, the paucity of available islets for transplantation as well as the immunological barriers faced in allogeneic transplantation represent a tremendous barrier to regenerative approaches to the treatment of diabetes. Here, we present a strategy and protocols to transdifferentiate developmentally related hepatocytes into beta-cells by the ectopic expression of critical beta-cell transcription factors.
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| http://dx.doi.org/10.1007/978-1-59745-060-7_25 | DOI Listing |
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