AI Article Synopsis
- * Two main culture systems for expanding multipotent progenitors are adhesive substrate bound cultures and neurosphere cultures, each with their own advantages and disadvantages.
- * The neurosphere culture mimics the brain's three-dimensional environment, offering insights into the regulation of neural stem cells and their potential therapeutic applications.
Article Abstract
Neural stem cells are potentially a source of cells not only for replacement therapy but also as drug vectors, bringing bioactive molecules into the brain. Stem cell-like cells can be isolated readily from the human brain, thus, it is important to find culture systems that enable expansion in a multipotent state to generate cells that are of potential use for therapy. Currently, two systems have been described for the maintenance and expansion of multipotent progenitors, an adhesive substrate bound and the neurosphere culture. Both systems have pros and cons, but the neurosphere may be able to simulate the three-dimensional environment of the niche in which the cells reside in vivo. Thus, the neurosphere, when used and cultured appropriately, can expand and provide important information about the mechanisms that potentially control neural stem cells in vivo.
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| http://dx.doi.org/10.1007/978-1-59745-060-7_9 | DOI Listing |
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