AI Article Synopsis
- The structures of these complexes were determined using single-crystal X-ray diffraction and were further characterized through various analytical techniques including NMR and mass spectrometry.
- In laboratory tests, these metal complexes demonstrated increased cytotoxicity against 11 human tumor cell lines compared to liriodenine alone, indicating that the combination of metal ions with liriodenine could enhance its cancer-fighting properties.
Article Abstract
Liriodenine (), an active component of the anticancer traditional Chinese medicine (TCM), was isolated from Zanthoxylum nitidum. Its reactions with Pt(II) and Ru(II) afforded three metal complexes: cis-[PtCl2(L)] (), cis-[PtCl2(L)(DMSO)] (), and cis-[RuCl2(L)(DMSO)2].1.5H2O (), the crystal structures of , and were determined by single-crystal X-ray diffraction methods. These complexes were fully characterized by elemental analysis, IR spectrophotometry, 1H and 13C NMR spectroscopies, and ES mass spectrometry. The in vitro cytotoxicity of and complexes against 11 human tumour cell lines was assayed. The metal-based compounds exhibit enhanced cytotoxicity vs. free , suggesting that these compounds display synergy in the combination of metal ions and liriodenine. The binding properties of and its complexes to ct-DNA were investigated through UV-vis, fluorescence, CD spectra, viscosity and agarose gels electrophoretic measurements.
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| http://dx.doi.org/10.1039/b813363h | DOI Listing |
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