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Plackett-Burman Design Combined with Response Surface Methodology to Recover Polysaccharides with Cardiovascular Protective Potential from Waste Zizania latifolia Bracts.
Chem Biodivers
January 2025
Changshu Institute of Technology, School of Biology and Food Engineering, No.99 South Third Ring Road (Donghu Campus), Changshu 215500,, 215500, Changshu, CHINA.
Zizania latifolia is the second aquatic vegetable in China. The circular valorization of its waste bracts remains ongoing concern. In this work, the cellulase-microwave-assisted extraction (CMAE) of polysaccharides from waste Z.
View Article and Find Full Text PDFCT-based nomogram predicts esophageal gastric variceal bleeding in noncirrhotic portal hypertension caused by hepatic schistosomiasis.
BMC Med Inform Decis Mak
January 2025
Department of Vascular and Wound Center, Jinshan Hospital, Fudan University, Shanghai, 201508, China.
Background: To construct a nomogram combining CT varices vein evaluation and clinical laboratory tests for predicting the risk of esophageal gastric variceal bleeding (EGVB) in patients with noncirrhotic portal hypertension (NCPH).
Methods: A total of 315 NCPH patients with non-EGVB and EGVB were retrospectively enrolled and randomly divided into training and testing cohorts. Thirteen collateral vessels were identified and evaluated after CT portal vein system reconstruction.
Altered thrombin generation with prothrombin complex concentrate is not detected by viscoelastic testing: an in vitro study.
Br J Anaesth
January 2025
Ludwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA, Vienna, Austria; Department of Anesthesiology and Intensive Care Medicine AUVA Trauma Center Salzburg, Academic Teaching Hospital of the Paracelsus Medical University, Salzburg, Austria.
Background: Bleeding guidelines currently recommend use of viscoelastic testing (VET) to direct haemostatic resuscitation in severe haemorrhage. However, VET-derived parameters of clot initiation, such as clotting time (CT) and activated clotting time (ACT), might not adequately reflect a clinically relevant interaction of procoagulant and anticoagulant activity, as revealed by thrombin generation assays. The aim of this study was to evaluate the ability of CT and ACT to indicate thrombin generation activity.
View Article and Find Full Text PDFProlonged prothrombin time in hyperemesis gravidarum as an indicator of vitamin K deficiency.
J Obstet Gynaecol Res
January 2025
Department of Obstetrics and Gynecology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
Article Synopsis
- The study investigates the impact of maternal vitamin K deficiency on fetal health, specifically in patients with severe hyperemesis gravidarum.
- Researchers compared coagulation factors in hyperemesis patients with those undergoing other procedures and found significant changes, particularly in prothrombin time.
- Timely vitamin K supplementation can normalize coagulation levels, potentially preventing serious fetal complications related to vitamin K deficiency.
[The Clinical Phenotype and Molecular Pathogenic Mechanism of a Family with Hereditary Coagulation Factor V Deficiency].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
December 2024
Department of Hematology, The Second Hospital of Shanxi Medical University, Taiyuan 030000, Shanxi Province, China.
Objective: To investigate the clinical phenotype and molecular pathogenic mechanism of a hereditary coagulation factor V deficiency (FⅤD) family.
Methods: A phase I assay was used to measure coagulation factors II, V, VII, VIII, IX, X, Ⅺ, Ⅻ (FⅡ∶C, FⅤ∶C, FⅦ∶C, FⅧ∶C, FⅨ∶C, FⅩ∶C, FⅪ∶C, FⅫ∶C), activated partial thromboplastin time (APTT) and prothrombin time (PT) to determine the clinical phenotype and molecular pathogenesis of F VD. Prothrombin time (PT) were used for phenotypic identification; high-throughput exome sequencing was applied to screen the whole gene variants, and Sanger sequencing was used to verify the suspected variants in gene; MutationTaster, PolyPhen-2 bioinformatics software was used to predict the pathogenicity of the variants, ClustalX software was used to analyze the amino acid conservatism, and PyMol software was used to simulate the model of the mutant protein.
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