Recent evidence suggests that sensitivity to the temporal fine structure (TFS) of sounds is adversely affected by cochlear hearing loss. This may partly explain the difficulties experienced by people with cochlear hearing loss in understanding speech when background sounds, especially fluctuating backgrounds, are present. We describe a test for assessing sensitivity to TFS. The test can be run using any PC with a sound card. The test involves discrimination of a harmonic complex tone (H), with a fundamental frequency F0, from a tone in which all harmonics are shifted upwards by the same amount in Hertz, resulting in an inharmonic tone (I). The phases of the components are selected randomly for every stimulus. Both tones have an envelope repetition rate equal to F0, but the tones differ in their TFS. To prevent discrimination based on spectral cues, all tones are passed through a fixed bandpass filter, usually centred at 11F0. A background noise is used to mask combination tones. The results show that, for normal-hearing subjects, learning effects are small, and the effect of the level of testing is also small. The test provides a simple, quick, and robust way to measure sensitivity to TFS.
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http://dx.doi.org/10.1080/14992020802475235 | DOI Listing |
The increasing availability of coarse-scale climate simulations and the need for ready-to-use high-resolution variables drive the climate community to the challenge of reducing computational resources and time for downscaling purposes. To this end, statistical downscaling is gaining interest as a potential strategy for integrating high-resolution climate information obtained through dynamical downscaling over limited years, providing a clear understanding of the gains and losses in combining dynamical and statistical downscaling. In this regard, several questions can be raised: (i) what is the performance of statistical downscaling, assuming dynamical downscaling as a reference over a shared time window; (ii) how much the performance of statistical downscaling is affected by changes in the number of years available for training; (iii) how does the climate normal considered for the training affect the predictions.
View Article and Find Full Text PDFEcotoxicol Environ Saf
January 2025
School of Public Health, Shanghai Jiao Tong University, Shanghai 200025, China. Electronic address:
The derivation of water quality criteria (WQC) for antibiotics is influenced by the inclusion of various organisms' toxicity data, including microbial data, though no definitive conclusions have been reached. This study focuses on sulfonamide antibiotics, common in the Yangtze River Delta (YRD), to assess the influences of different organisms' toxicity data on determining WQCs and subsequent evaluation of ecological risks. A total of 263 toxicity data points from eight sulfonamides, including sulfamethoxazole (SMX) and sulfamethazine (SM2), were selected to derive WQCs using Species Sensitivity Distribution (SSD) methods.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
January 2025
Department of Communication Science and Disorders, University of Pittsburgh, Pittsburgh, PA 15213.
The auditory system is unique among sensory systems in its ability to phase lock to and precisely follow very fast cycle-by-cycle fluctuations in the phase of sound-driven cochlear vibrations. Yet, the perceptual role of this temporal fine structure (TFS) code is debated. This fundamental gap is attributable to our inability to experimentally manipulate TFS cues without altering other perceptually relevant cues.
View Article and Find Full Text PDFPLoS One
January 2025
Department of Developmental Epileptology, Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic.
Seizures elicited by corneal 6-Hz stimulation are widely acknowledged as a model of temporal lobe seizures. Despite the intensive research in rodents, no studies hint at this model in developing animals. We focused on seven age groups of both male and female rats.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Boston Children's Hospital, Boston, MA, USA.
Background: Alzheimer's disease (AD), an age-associated neurodegenerative disorder, is characterized by progressive neuronal loss and the accumulation of misfolded proteins such as amyloid-β and tau. While neuroinflammation, mediated by microglia and brain-resident macrophages, plays a pivotal role in AD pathogenesis, the intricate interactions among age, genes, and other risk factors remain elusive. Somatic mutations, known to accumulate with age, instigate clonal expansion across diverse cell types, impacting both cancer and non-cancerous conditions.
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