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Consensus Recommendations for Studies of Outflow Facility and Intraocular Pressure Regulation Using Ex Vivo Perfusion Approaches.
Invest Ophthalmol Vis Sci
December 2024
Department of Ophthalmology, Duke University, Durham, North Carolina, United States.
Intraocular pressure (IOP) elevation is the primary risk factor and currently the main treatable factor for progression of glaucomatous optic neuropathy. In addition to direct clinical and living animal in vivo studies, ex vivo perfusion of anterior segments and whole eyes is a key technique for studying conventional outflow function as it is responsible for IOP regulation. We present well-tested experimental details, protocols, considerations, advantages, and limitations of several ex vivo model systems for studying IOP regulation.
View Article and Find Full Text PDFDoes Cognitive Load Affect Measures of Consciousness?
Brain Sci
September 2024
Vestre Viken Klinisk Nevrofysiologi, Kongsberg Hospital, Vestre Viken Health Trust, 3004 Drammen, Norway.
Background: Developing and testing methods for reliably measuring the state of consciousness of individuals is important for both basic research and clinical purposes. In recent years, several promising measures of consciousness, grounded in theoretical developments, have been proposed. However, the degrees to which these measures are affected by changes in brain activity that are not related to changes in the degree of consciousness has not been well tested.
View Article and Find Full Text PDFElectric Field Dependence of EPR Hyperfine Coupling Constants.
J Phys Chem A
September 2024
Institute of Chemistry, University of Silesia in Katowice, Szkolna 9, 40-006 Katowice, Poland.
In this article, we introduce a simple but reliable method to calculate the electric field dependence of the isotropic hyperfine coupling tensor for free radicals. This dependence, also referred to as the Bloembergen effect, can be of interest in analyzing EPR experiments for solid-state materials but is rarely studied for isolated radicals in the gaseous phase. The proposed method uses the numerical differentiation of the field-perturbed tensor and, consequently, as a purely numerical method, does not depend on a quantum chemical method used to determine the hyperfine tensor .
View Article and Find Full Text PDFReconnaissance of Allostery via the Restoration of Native p53 DNA-Binding Domain Dynamics in Y220C Mutant p53 Tumor Suppressor Protein.
ACS Omega
May 2024
College of Integrated Sciences, Wesleyan University, Hall-Atwater Laboratories, Middletown, Connecticut 06459-0180, United States.
Allosteric regulation of protein dynamics infers a long-range deliberate propagation of information via micro- and macroscale interactions. The Y220C structural mutant is one of the most frequent cancerous p53 mutants. The mutation is distally located from the DNA-binding site of the p53 DNA-binding domain yet causes changes in DNA recognition.
View Article and Find Full Text PDFA brief review of complex regional pain syndrome and current management.
Ann Med
December 2024
Department of Anesthesiology, Medical College of Wisconsin, Wauwatosa, WI, USA.
Complex regional pain syndrome (CRPS) is a debilitating chronic pain condition that, although exceedingly rare, carries a significant burden for the affected patient population. The complex and ambiguous pathophysiology of this condition further complicates clinical management and therapeutic interventions. Furthermore, being a diagnosis of exclusion requires a diligent workup to ensure an accurate diagnosis and subsequent targeted management.
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