Background: Dual-source computed tomography (DSCT) was introduced with significant hardware and software changes compared with single-source CT (SSCT), resulting in improved temporal resolution (83 ms) and the potential for improved image quality. The effect of these changes on radiation dose requirements for coronary CT angiography in clinical practice has not been investigated.
Objective: We evaluated patient radiation dose and image quality of electrocardiogram (ECG)-gated helical techniques, using DSCT compared with SSCT for clinical imaging of the coronary arteries.
Methods: DSCT data from 160 patients were evaluated; 82 patients (DSCT group 1) were imaged with early software, and 78 patients (DSCT group 2) were imaged with a later software version. Patients imaged with SSCT (n = 124) were the control group. Effective radiation dose values were estimated for all patients. Image noise was measured, and image quality was evaluated on a 5-point scale.
Results: Effective dose values for DSCT group 2 (11.7 +/- 4.0 mSv) were not different from those for SSCT group (10.9 +/- 2.9 mSv); the highest doses, 13.2 +/- 3.2 mSv, were recorded for DSCT group 1 (P < 0.001). A decrease in image noise was observed for DSCT compared with SSCT (P
Conclusion: ECG-gated helical DSCT can provide images of the coronary arteries with improved image quality and decreased noise without an increase in radiation dose compared with SSCT in clinical patient groups.
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http://dx.doi.org/10.1016/j.jcct.2008.09.003 | DOI Listing |
Dentomaxillofac Radiol
January 2025
Assist. Prof. Dr, Selcuk University Faculty of Medicine, Department of Radiation Oncology, Konya, 42130, Turkiye.
Objectives: Due to the increasing use of cone-beam computed tomography (CBCT) in dentistry and considering the effects of radiation on radiosensitive organs, the aim of this study was to investigate the effect of shielding on absorbed dose of eyes, thyroid and breasts in scans conducted with different parameters using two different fields of view (FOV).
Methods: Dose measurements were calculated on a tissue-equivalent female phantom by repeating each scanning parameter three times and placing at least two thermoluminescent dosimeters (TLD) on each organ, with the averages then taken. The same CBCT scans were performed in two different FOV with shielding including thyroid collar, radiation safety glasses and lead apron and without shielding.
Oncologist
January 2025
Department of Orthopaedic Surgery, Division of Surgical Specialties, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
This narrative review provides a comprehensive overview of the current status, recent advancements, and future directions in the management of metastatic spine disease using both radiotherapy and surgery. Emphasis has been put on the integrated use of radiotherapy and surgery, incorporating recent developments such as separation surgery, active dose sparing of the surgical field, and the implementation of carbon fiber-reinforced polymer implants. Future studies should explore the effects of minimizing the time between radiotherapy and surgery and investigate the potential of vertebral re-ossification after radiotherapy to obviate the need for stabilization surgery.
View Article and Find Full Text PDFEJNMMI Phys
January 2025
Department of Nuclear Medicine, Rambam Health Care Campus, P.O.B. 9602, 3109601, Haifa, Israel.
Background: A recently released digital solid-state positron emission tomography/x-ray CT (PET/CT) scanner with bismuth germanate (BGO) scintillators provides an artificial intelligence (AI) based system for automatic patient positioning. The efficacy of this digital-BGO system in patient placement at the isocenter and its impact on image quality and radiation exposure was evaluated.
Method: The digital-BGO PET/CT with AI-based auto-positioning was compared (χ, Mann-Whitney tests) to a solid-state lutetium-yttrium oxyorthosilicate (digital-LYSO) PET/CT with manual patient positioning (n = 432 and 343 studies each, respectively), with results split into groups before and after the date of a recalibration of the digital-BGO auto-positioning camera.
Eur Heart J
January 2025
School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 2199 Lishui Rd, Nanshan, Shenzhen, Guangdong Province 518055, China.
Background And Aims: Lackluster results from recently completed gene therapy clinical trials of VEGF-A delivered by viral vectors have heightened the need to develop alternative delivery strategies. This study aims to demonstrate the pre-clinical efficacy and safety of extracellular vesicles (EVs) loaded with VEGF-A mRNA for the treatment of ischaemic vascular disease.
Methods: After encapsulation of full-length VEGF-A mRNA into fibroblast-derived EVs via cellular nanoporation (CNP), collected VEGF-A EVs were delivered into mouse models of ischaemic injury.
PurposeThe concept of dual-state hyper-energy metabolism characterized by elevated glycolysis and OxPhos has gained considerable attention during tumor growth and metastasis in different malignancies. However, it is largely unknown how such metabolic phenotypes influence the radiation response in aggressive cancers. Therefore, the present study aimed to investigate the impact of hyper-energy metabolism (increased glycolysis and OxPhos) on the radiation response of a human glioma cell line.
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