AI Article Synopsis
- Researchers aimed to enhance the prognosis of acute pancreatitis by evaluating the effectiveness of four serum markers (CRP, IL-6, IL-10, PAP) compared to Ranson's score.
- A study of 71 patients revealed that severe cases showed higher levels of all markers, with IL-10 demonstrating greater predictive accuracy than Ranson's score.
- Timing of patient admission significantly affected the markers' predictive power, with IL-6, IL-10, and PAP being more accurate within the first 48 hours, while CRP excelled afterward, indicating the importance of considering the time of evolution in prognosis.
Article Abstract
Improving the outcome of acute pancreatitis through prognostic markers has been a matter of ample research. We evaluate the clinical usefulness of four serum markers in comparison to Ranson's score. Serum measurements of C-reactive protein (CRP), interleukin-6, -10 (IL-6, IL-10), and pancreatitis-associated protein (PAP) were performed. The usefulness of each marker for predicting severity was compared with that of Ranson's score. Time of evolution was considered for improving their usefulness. Seventy-one patients were studied. Severe cases had higher levels of all markers, although only IL-10 had better accuracy than Ranson's. In patients admitted during the first 48 h, IL-6, IL-10, and PAP had improved accuracy over Ranson's; however, after this time frame, only CRP outperformed Ranson's score. Analysis of time frames improved the accuracy of all markers. Therefore, time of evolution should be considered when using these parameters for a better prognosis.
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| http://dx.doi.org/10.1007/s10620-008-0615-1 | DOI Listing |
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