AI Article Synopsis
- The review examines the effectiveness of using frozen sections during radical prostatectomy for reducing positive surgical margins and its influence on postoperative PSA levels.
- The data was collected from various studies accessed through Pubmed, focusing on specific terms related to prostate surgery and frozen sections.
- There is currently no standardized approach regarding when and where to perform frozen sections during surgery, and evidence does not conclusively support improvements in patient outcomes.
Article Abstract
Purpose: To review the evidence about frozen sections during radical prostatectomy (RP) and its ability to decrease the incidence of positive margins, the impact on PSA postoperatively and the significance of residual benign prostatic cells after prostatectomy.
Methods: The information for this review was compiled by searching the Pubmed database. We used Mesh Terms "Prostatectomy" and "Prostatic Neoplasms" and we added "frozen sections" and/or "hyperplasic cells" and/or "benign cells" and/or "positive margins". Furthermore, we review the articles referenced in those studies and editorials letters.
Results: Several groups have studied the performance of frozen section during RP to try and assess the risk of positive margins intraoperatively. The controversial sites where they should be performed are the apex, the dorsolateral zones and the bladder neck. They have been performed routinely or when the surgeon decides it, depending on the preoperative or intraoperative findings.
Conclusions: At the present time there is no standardisation in the number, the site and the type of patient where this procedure should be done. The improvement in functional outcomes and biochemical control is not proven.
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| http://dx.doi.org/10.1007/s00345-008-0360-2 | DOI Listing |
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