Discovery and optimisation of a potent and selective tertiary sulfonamide oxytocin antagonist.

Bioorg Med Chem Lett

GlaxoSmithKline Pharmaceuticals, New Frontiers Science Park (North), Coldharbour Road, Harlow, Essex CM19 5AD, England, UK.

Published: January 2009

The optimisation of a tertiary sulfonamide high-throughput screening hit is described. A combination of high-throughput chemistry, pharmacophore analysis and in silico PK profiling resulted in the discovery of potent sulfonamide oxytocin receptor antagonists with oral exposure and good selectivity over vasopressin receptors.

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http://dx.doi.org/10.1016/j.bmcl.2008.11.018DOI Listing

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