In a paper in this issue of Developmental Cell, Shibutani et al. (2008) uncover the mechanism that underlies tightly regulated S-phase degradation of Drosophila E2F1 during development. They show that dE2F1 is degraded by the Cul4(Cdt2) ubiquitin ligase in a manner that resembles the DNA replication-dependent turnover of Cdt1.
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| http://dx.doi.org/10.1016/j.devcel.2008.11.007 | DOI Listing |
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