Objective: To evaluate the clinical efficacy and safety of acute hypervolemic hemodilution (AHH) in posterior spinal fusion surgery in children.
Methods: 36 children with scoliosis ASA I approximately II, receive of posterior spinal fusion, were randomly divided into 2 equal groups: AHH group, transfused with hydroxyethyl starch 130/0.4 and sodium chloride (Voluven) 12 ml/kg at the speed of 0.3 approximately 0.4 mlxkg(-1)xmin(-1) (for 30 approximately 40 min) through internal jugular vein before operation so as to keep the hemodilution (Hb) status during operation, and control (CNT) group. During operation when the Hb was <80 g/L or the hematocrit was < 25% blood transfusion was conducted to maintain the Hct > 25%.
Results: There was no significant difference in intra-operative blood loss between these 2 groups. The Hb one day after operation of the AHH group was (89 +/- 12) g/L, significantly lower than that immediately after operation [(98 +/- 10) g/L, P < 0.05]. The Hb one day after operation of the CNT group was (92 +/- 22) g/L, significantly lower than that immediately after operation [(94 +/- 13) g/L, P < 0.05]. However, there were not significant differences in the Hb values between the AHH and CNT groups (all P > 0.05). Both groups received intra-operative transfusion during operation. The amount of transfused red blood cells and fresh frozen plasma of the AHH group were (18 +/- 4) ml/kg and (3.5 +/- 1.1) ml/kg respectively, both significantly lower than those of the CNT group [(28 +/- 11) and (5.8 +/- 1.8) ml/kg respectively, both P < 0.05].
Conclusion: Able to reduce intra-operative blood transfusion and medical expense, AHH can be used safely and effectively in posterior spine fusion in children.
Download full-text PDF |
Source |
---|
Health Policy Plan
October 2024
Department of Humanities and Social Sciences, Indian Institute of Technology-Madras, Chennai, India.
The capacity of government agencies to develop effective policy responses to external shocks is an important area of focus for health policy processes, as illustrated by the COVID-19 pandemic. However, few empirical studies exploring sub-national capacity of governments and the influence of institutional, organizational and political factors in shaping the policy response to complex emergencies have been conducted. The purpose of this study is to examine the governance capacity to develop and implement a policy response to a major health emergency-COVID-19-in Tamil Nadu, India, and to understand the factors shaping governance capacity during the first and second waves (2020-2021).
View Article and Find Full Text PDFInt J Stroke
July 2024
Neurology Department, Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST), Trivandrum, India.
Background: There are little data on the use of smartphone-based applications for medication adherence and risk-factor control for the secondary prevention of stroke in low-and-middle-income countries (LMICs).
Aims: The aim was to determine whether a smartphone-based app improved medication adherence, risk-factor control, and provided health education to stroke survivors for lifestyle and behavioral modifications.
Methods: An unblinded, single-center randomized controlled double arm trial with 1:1 allocation among stroke survivors was performed in South India.
Eur J Clin Invest
January 2023
Gastroenterology Unit, Department of Internal Medicine, IRCCS Ospedale Policlinico San Martino, University of Genoa, Genoa, Italy.
Aim: To evaluate the impact of antiplatelet therapy (APT)on the incidence of hepatocellular carcinoma (HCC) and mortality following its treatment.
Methods: A systematic literature search was performed using PubMed and Cochrane Central Register of Controlled Trials Databases. Two HCC clinical settings were explored: (i) incidence, and (ii) death after any HCC treatment.
Biochem J
November 2020
School of Biotechnology, Jawaharlal Nehru University, New Delhi 110067, India.
Drug repurposing is an alternative avenue for identifying new drugs to treat tuberculosis (TB). Despite the broad-range of anti-tubercular drugs, the emergence of multi-drug-resistant and extensively drug-resistant strains of Mycobacterium tuberculosis (Mtb) H37Rv, as well as the significant death toll globally, necessitates the development of new and effective drugs to treat TB. In this study, we have employed a drug repurposing approach to address this drug resistance problem by screening the drugbank database to identify novel inhibitors of the Mtb target enzyme, DNA gyrase.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!