A general method for the preparation of bis-ureas from bis(o-nitrophenyl) carbonate has been developed. Directional urea synthesis is achieved by sequential amine addition to bis(o-nitrophenyl) carbonate in two steps: in the first step bis(o-nitrophenyl) carbonate is reacted with benzylamine to form benzyl-o-nitrophenyl carbamate; in the second step the carbamate is reacted with a variety of diamines in toluene to yield bis-ureas.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244956 | PMC |
| http://dx.doi.org/10.3390/molecules13123192 | DOI Listing |
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