AI Article Synopsis
- The study investigates the impact of oxidative stress (OS) and asymmetric dimethylarginine (ADMA) on endothelial function (EF) in peritoneal dialysis (PD) patients, specifically focusing on those without known atherosclerotic disease.
- Findings reveal that PD patients exhibit significantly higher levels of oxidative stress markers and lower endothelial function compared to healthy individuals, indicating a deterioration in vascular health.
- A key correlation is established, showing that advanced oxidation protein products (AOPP) are independently linked to impaired endothelial function, suggesting they could serve as indicators for vascular issues in these patients.
Article Abstract
Aim: Oxidative stress (OS) and asymmetric dimethylarginine (ADMA) are accepted as non-classical cardiovascular risk factors in end-stage renal disease patients. To clarify the role of these factors in the atherosclerotic process, we investigated if OS and ADMA are associated with endothelial function (EF) in peritoneal dialysis (PD) patients.
Methods: Fifty-two non-diabetic PD patients without known atherosclerotic disease as well as 30 age- and sex-matched healthy individuals were included. We measured serum thiobarbituric acid-reactive substances (TBARS), malondialdehyde (MDA), advanced glycation end-product (AGE), pentosidine, advanced oxidation protein products (AOPP), ADMA and EF as described by Celermejer et al. in all subjects.
Results: TBARS, MDA, AOPP, AGE, pentosidine and ADMA levels were significantly higher in PD patients than in controls (P < 0.001). Flow-mediated dilatation (FMD)% and nitrate mediated dilatation (NMD)% in PD patients were lower than in the control group (7.7 +/- 4.0% vs 11.70 +/- 5.50%, P < 0.01 and 17.6 +/- 8.3% vs 26.4 +/- 4.6%, P < 0.01). Additionally, it was found that AOPP are independently correlated with FMD% and NMD% in PD patients (beta = -463, P < 0.01 and beta = -420, P < 0.05).
Conclusion: This study shows that PD patients without known atherosclerotic disease can also be characterized by endothelial dysfunction and AOPP levels independently predict endothelial function level in PD patients.
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| http://dx.doi.org/10.1111/j.1440-1797.2008.01062.x | DOI Listing |
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