Efficient cleavage of Bid and procaspase-7 by caspase-2 at lower pH.

Protein Pept Lett

Research Center for Proteineous Materials (RCPM), Department of Bio-Materials Engineering, School of Medicine, College of Natural Sciences, Chosun University, Gwangju, 501-759, Republic of Korea.

Published: January 2009

The activity of caspase-2 was examined under varying biochemical conditions with the synthetic and protein substrates, Bid and procaspase-7. The results indicate that it was largely influenced by pH which might be one reason behind the inconsistency for the cleavage of its established substrates during caspase-2-induced apoptosis.

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http://dx.doi.org/10.2174/092986608786071193DOI Listing

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