Zygomycosis and aspergillosis are two serious opportunistic fungal infections that are commonly seen in immunocompromised patients. Since both these fungi invade vessels of the arterial system, an early and rapid diagnosis by direct examination of KOH mounts of the relevant clinical sample can confirm the diagnosis. Here, we present an unusual case of a diabetic patient who presented with nasal blockade and bleeding for 2 months, along with occasional haemoptysis for 15 days. On investigation, the patient was diagnosed with a case of rhinocerebral zygomycosis and was treated with amphotericin B (1 mg kg(-1) day(-1)), which was subsequently replaced with liposomal amphotericin B (2 mg kg(-1) day(-1)). However, the patient did not completely respond to therapy as haemoptysis continued. Further investigations revealed the presence of Aspergillus flavus in respiratory specimens. Thus, a final diagnosis of rhinocerebral zygomycosis with pulmonary aspergillosis in a non-HIV-infected patient was made, but due to infection of two vital sites by these fungi, the patient could not be saved.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1099/jmm.0.005272-0 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Rhino-orbital-cerebral mucormycosis in acute myeloid leukemia patients: a case series from Sri Lanka.
BMC Infect Dis
December 2024
National Cancer Institute, Maharagama, Sri Lanka.
Background: Mucormycosis, is a rare yet potentially life-threatening fungal infection common in immunocompromised patients. Despite optimal care, mucormycosis in haemato-oncological patients often results in poor outcomes. This case series details the presentations and unique challenges faced during the management of patients with acute myeloid leukemia who developed rhino-cerebral mucormycosis.
View Article and Find Full Text PDFEpidemiological Trends of Mucormycosis in Europe, Comparison with Other Continents.
Mycopathologia
November 2024
Fourth Department of Internal Medicine, General University Hospital "Attikon", National and Kapodistrian University of Athens, 12462, Athens, Greece.
Article Synopsis
- * The incidence in developed countries is relatively low (0.06 to 0.3 cases per 100,000), but in India, it spikes to about 14 cases per 100,000, making it significantly more prevalent there than in Europe, where rates range from 0.04 to 0.12.
- * Diabetes mellitus is the most common risk factor globally for mucormycosis, with varying patterns; in Europe, hematological cancers are more prevalent, while the disease often appears in patients
Rhinocerebral mucormycosis: A clinicopathological analysis of COVID-19-associated mucormycosis.
J Family Med Prim Care
August 2024
Department of Pathology, Government Doon Medical College, Dehradun, Uttarakhand, India.
Article Synopsis
- - The study investigates the rise of mucormycosis cases linked to post-COVID-19 infection, identifying risk factors and examining clinical and histopathological features.
- - Conducted in a hospital in India, the research analyzed surgical specimens over two months, confirming mucormycosis in 9 out of 25 clinically suspected cases, with significant findings related to diabetes as a comorbidity.
- - Results highlight a heavy fungal load and severe complications in diabetic patients; emphasizing the importance of early diagnosis through histopathological methods for better treatment outcomes.
Epidemiology and prognostic factors of mucormycosis in France (2012-2022): a cross-sectional study nested in a prospective surveillance programme.
Lancet Reg Health Eur
October 2024
Institut Pasteur, Paris Cité University, National Reference Center for Invasives Mycoses and Antifungals, Mycology Department, Paris, France.
Article Synopsis
- Mucormycosis, a severe fungal infection highlighted by the WHO, was studied in France from 2012 to 2022, revealing significant trends in epidemiology and mortality factors.
- Out of 550 cases, key underlying conditions included hematological malignancies (65.1%), with pulmonary infections most common (52.4%) and substantial seasonal variations suggesting more cases in autumn.
- The study linked the rise in PCR diagnostic methods to improved patient outcomes, highlighting that age, ICU diagnosis, and hematological malignancies increased mortality, while diagnosis after 2015 and surgical interventions decreased it.
Clinical characteristics and mortality of mucormycosis in hematological malignancies: a retrospective study in Eastern China.
Ann Clin Microbiol Antimicrob
August 2024
Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, Anhui, China.
Article Synopsis
- Mucormycosis is a serious fungal infection that significantly impacts patients with blood cancers in eastern China, with this study focusing on its clinical features from 2018 to 2023.
- A total of 50 cases were analyzed, revealing that most patients were young adults (average age 40) predominantly suffering from acute myeloid leukemia, with pulmonary manifestations being the most common.
- The study found a high 90-day mortality rate of 76%, highlighting that early diagnosis and treatment with amphotericin B and surgery can improve survival rates, while certain factors like neutropenia worsen outcomes.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!