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Progress and challenges in the elimination of hepatitis C among people who inject drugs in Germany: results of a pilot study for a national monitoring system, 10 years after the first data collection.
Harm Reduct J
December 2024
Department of Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany.
Background: People who inject drugs (PWID) are at high risk of blood-borne infections, and injection drug use contributes significantly to hepatitis C virus (HCV) transmission. The WHO has therefore set targets of reducing HCV incidence and prevalence among PWID and increasing treatment coverage to eliminate HCV by 2030. The DRUCK study (2011-2014) found high HCV prevalence and low treatment coverage among PWID in Germany.
View Article and Find Full Text PDFPhotoactivatable O-GlcNAc Transferase Library Enables Covalent Chemical Capture of Solvent-Exposed TPR Domain Interactions.
Chembiochem
January 2025
Department of Chemistry, St. Olaf College, 1520 St. Olaf Ave., Northfield, MN, 55057.
O-linked N-acetylglucosamine (O-GlcNAc) transferase (OGT) is an essential, stress-sensing enzyme responsible for adding the O-GlcNAc monosaccharide to thousands of nuclear and cytoplasmic proteins to regulate cellular homeostasis. OGT substrates are found in almost all intracellular processes, and perturbations in protein O-GlcNAc levels have been implicated in proteostatic diseases, such as cancers, metabolic disorders, and neurodegeneration. This broad disease activity makes OGT an attractive therapeutic target; however, the substrate diversity makes pan-inhibition as a therapeutic strategy unfeasible.
View Article and Find Full Text PDFModel matchmaking via the Solve-RD Rare Disease Models & Mechanisms Network (RDMM-Europe).
Lab Anim (NY)
July 2024
Institute of Medical Genetics and Applied Genomics, University of Tübingen, Tübingen, Germany.
Article Synopsis
- In biomedical research for rare diseases, model organisms are essential for understanding disease mechanisms, identifying biomarkers, and developing therapies.
- Solve-RD is an EU-funded project focused on addressing numerous previously unresolved rare diseases.
- The project has led to the creation of the European Rare Disease Models & Mechanisms Network (RDMM-Europe) to enhance research efforts in this area.
Acceptance and feasibility of a low-threshold and substitution services-based periodical monitoring system for blood-borne and sexually transmitted infections among people who inject drugs in Germany: a mixed-methods analysis.
Harm Reduct J
March 2024
Department of Infectious Disease Epidemiology, Robert Koch Institute, Nordufer 20, 13353, Berlin, Germany.
Background: To reach the global elimination goals of viral hepatitis B and C (HBC, HCV), human immunodeficiency virus (HIV) and other sexually transmitted infections as a public health threat by 2030, monitoring is needed. Staff members of drug services and opioid substitution treatment (OST) practices in Berlin and Bavaria recruited clients for a pilot study addressing the respective infections among people who injected drugs (PWID) in Germany, 2021/2022. Participants filled a questionnaire and were tested for HBV, HCV, HIV and syphilis using dried blood spots (DBS).
View Article and Find Full Text PDFMonthly video consultation for children and adolescents with type 1 diabetes mellitus during the COVID-19 pandemic.
Diabetes Res Clin Pract
November 2022
Hannover Medical School, Medical Psychology, Carl-Neuberg Straße 1, 30625 Hannover, Germany. Electronic address:
Aims: To explore the impact of primarily telemedical care for children and adolescents with type 1 diabetes by monthly video consultations on metabolic control and parents' treatment satisfaction and disease-specific burden during the COVID-19 pandemic.
Methods: In this 12-month multicenter observational follow-up VIDIKI 2.0 study, 100 participants (3-18 years) received monthly video consultations, which partially replaced quarterly outpatient clinic appointments during the pandemic.
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