A bare graphite-polyurethane composite was evaluated as an alternative electrode in the determination of atenolol (ATN) in pharmaceutical formulations. Using a DPV procedure, a linear analytical curve was observed in the 4-100mumolL(-1) range with a LOD=3.16mumolL(-1), without need of surface renewing between successive runs, with recoveries between 95.5 and 108%. Interference of other antihypertensive drugs was observed, but not from the usual components of tablets. The results of the proposed method agreed with HPLC ones within 95% confidence level.
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http://dx.doi.org/10.1016/j.talanta.2006.10.017 | DOI Listing |
Diagn Microbiol Infect Dis
January 2025
Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China; Institute of Neurosurgery of People's Liberation Army of China (PLA), PLA's Key Laboratory of Critical Care Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China. Electronic address:
Background: To construct a nomogram and a Randomized Survival Forest (RSF) model for predicting the occurrence of sepsis in patients with cerebral infarction in intensive care units (ICUs).
Methods: A total of 1,963 patients were included from the Medical Information Mart for Intensive Care IV database version 2.0 (MIMIC-IV v2.
Chirality
January 2025
Department of Chemistry, Shyam Lal College, University of Delhi, New Delhi, India.
Enantiomeric analysis of chiral drugs is very significant, as their enantiomers display different pharmacological or toxicological behavior towards living systems. Among these drugs, β-blockers are available as racemates, where their enantiomers display different pharmacological effects. Herein, we report enantioselective separation of two β-blockers, namely, atenolol and sotalol, using a derivatization approach.
View Article and Find Full Text PDFBiochem Biophys Res Commun
January 2025
Cleveland Diagnostics, 3615 Superior Ave., Cleveland, OH, 44114, USA. Electronic address:
The partition coefficient of human serum albumin (HSA) was analyzed in the PEG600-Dex70, 0.15 M NaCl/KCl in 0.01 M Na/K phosphate buffer, pH 7.
View Article and Find Full Text PDFJ Bone Miner Res
December 2024
Division of Endocrinology and Kogod Center on Aging, Mayo Clinic, Rochester, MN.
Motivated by studies showing an association between beta blocker (BB) use and positive bone outcomes, a pilot randomized control trial (RCT) was performed at the Mayo Clinic which randomized postmenopausal women to placebo, propranolol (40 or 80 mg twice daily), atenolol (50 mg/day), or nebivolol (5 mg/day) to determine changes in bone turnover markers (BTMs) and in bone mineral density (BMD) over 20 weeks. Pharmacogenetic effects and microRNA-mediated mechanisms involving beta adrenergic receptor and related genes have previously been found. We sought to validate these effects and discover new candidates in an ancillary study to the pilot clinical trial.
View Article and Find Full Text PDFTransl Pediatr
November 2024
Department of Endocrinology and Inherited Metabolic Diseases, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Background: Mendelian randomization (MR) has been used to identify drug targets in many conditions. Height is a classic complex trait affected by genetic and early-life environmental factors. No systematic screening has been conducted to identify drugs that interact with height.
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