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Anti-Pseudomonas Aeruginosa Bacteriophage Loaded Electrospun Fibers for Antibacterial Wound Dressings.
Macromol Rapid Commun
January 2025
UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London, WC1N 1AX, UK.
Antimicrobial resistance poses a growing threat to public health globally. Multidrug resistant Pseudomonas (P.) aeruginosa is detected in many infected wounds and is very challenging to treat with antibiotics.
View Article and Find Full Text PDFIsolation from Urine Culture in Hospitalised Patients: Incidence of Complicated Urinary Tract Infections and Asymptomatic Bacteriurias and Impact on Treatment of the EUCAST 2020 Update.
Antibiotics (Basel)
December 2024
Infectious Diseases Clinic, Santa Maria della Misericordia Hospital, Department of Medicine, University of Perugia, Piazzale Menghini 1, 06132 Perugia, Italy.
Urinary tract infections (UTIs) and asymptomatic bacteriurias (ABU) represent a large field of interest for antimicrobial stewardship programmes especially after 2020 EUCAST update in antimicrobial susceptibility testing interpretation and the possible related increase in carbapenems' prescription rate. The aim of this study was to evaluate the impact of the 2020 EUCAST update on antibiotic prescription in UTI due to organism and their characteristics. A retrospective observational study.
View Article and Find Full Text PDFEvaluating racial and ethnic disparities in antibiotic treatment for pneumonia patients in a major academic health system.
Antimicrob Steward Healthc Epidemiol
December 2024
Division of Infectious Diseases, Department of Medicine, School of Medicine, Emory University, Atlanta, GA, USA.
Objective: Examine the relationship between patients' race and prescriber antibiotic choice while accounting for differences in underlying illness and infection severity.
Design: Retrospective cohort analysis.
Setting: Acute care facilities within an academic healthcare system.
Characterization, immobilization and evaluation of anti-Pseudomonas aeruginosa biofilm activity of alginate lyase from marine bacterium, Enterobacter tabaci RAU2C.
Biotechnol Lett
November 2024
Department of Biotechnology, Kalasalingam Academy of Research and Education, Krishnankoil, Tamil Nadu, 626 126, India.
Article Synopsis
- * The study involved characterizing both free and immobilized forms of the enzyme, with optimal activity found at 37°C and pH 7.0, and a specific immobilization method proving to be more effective.
- * Results demonstrated that the alginate lyase could both inhibit the formation of and disrupt existing biofilms, indicating its potential efficacy in treating infections caused by P. aeruginosa.
Enhanced Efficacy of Some Antibiotics in the Presence of Silver Nanoparticles Against Clinical Isolate of Recovered from Cystic Fibrosis Patients.
Int J Nanomedicine
November 2024
Translational and Clinical Research Institute, Newcastle University Medical School, Newcastle Upon Tyne, NE2 4HH UK.
Introduction: Given the increasing frequency of drug-resistant bacteria and the limited progress in developing new antibiotics, it is necessary to explore new methods of combating microbial infections. Nanoparticles, particularly silver nanoparticles (Ag-NPs), have shown exceptional antibacterial characteristics; however, elevated concentrations of Ag-NPs can produce noticeable levels of toxicity in mammalian cells.
Aim: This study examined the potential synergistic effect of combining a low dosage of Ag-NPs and anti-pseudomonas drugs against (ATCC strain) and eleven clinical isolates from cystic fibrosis patients.
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