[Glycosaminoglycans dysbolism in pathogenesis of idiopathic varicocele].

Ultrasound dopplerography (UD) was used to examine 50 patients with idiopathic varicocele (IV) and 20 healthy subjects. Such parameters were assessed as age, severity of IV, its duration, scrotal vessels UD data, vein diameter of the pampiniform plexus on the left, reflux at the height of the Valsalva test, uronic acids (UA), glycosaminoglycanes (GAG) and their fractions (hialuronic acid--HA, chondroitin sulphates--CS, heparansulphates--HS). UA and GAG fraction composition was studied with ion exchange chromatography. Calculations were made of mean values, standard deviations, Student's t-criterion, Pirson's correlation coefficient. It was found that HA and UA concentrations were high. In young patients HA metabolism was disturbed more, in adult patients--disturbance of UA metabolism. Two equal negative moderately strong links were revealed between the patients' age, HS and total GAG: r1 = r2 = -0.56; CI of UA in the patients--21.97-59.09 mcg/ml, in the control group --23.70- 43.42 mcg/ml. With age, the organism adapts to the disease and spontaneous regress may occur. In UA concentration in the serum above 43.42 mcg/ml surgical treatment is indicated, if it is lower--conservative treatment and follow-up.