The localization and morphometric features of the preganglionic neurons of the spinal sacral parasympathetic nucleus innervating the descending colon and the rectum, were studied in cats, anesthetized with urethane (1.5 g/kg intraperitoneally) using the method of retrograde horseradish peroxidase transport. The solution of the marker was injected under the serosa of the indicated areas of the colon. After 48 h the animals were transcardially perfused with a fixative solution. Frontal sections of the sacral spinal segments were prepared and stained according to M. Mezulam's protocol (1978). It was demonstrated that the indicated areas of the colon were innervated by the neurons of the sacral parasympathetic nucleus, located in SI, SII and SIII segments of the spinal cord. The majority of the labeled cells were observed within SII segment. The neurons of this nucleus, which innervated the indicated areas of the colon, formed two longitudinal groups (lateral and dorsal ones), the cells in which differed by their sizes and longitudinal axis orientation. Most of the labeled cells were detected in the lateral group.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Novel Concepts on the Functional Neuroanatomy of the Anorectum: Implications for Anorectal Neuropathy and Neuromodulation Therapy.
Am J Gastroenterol
November 2024
Division of Neurogastroenterology/Motility, Medical College of Georgia, Augusta University, Augusta, Georgia.
Anorectal neuropathy causes anorectal dysfunction, yet it is poorly recognized. This stems from both a lack of understanding of the extrinsic and intrinsic innervation of the anorectum and tools for evaluation of neuronal function. Our objective was to provide an improved understanding of the neuronal networks of the anorectum and discuss its functional significance.
View Article and Find Full Text PDFAging-related NADPH diaphorase positive neurodegenerations in the sacral spinal cord of aged non-human primates.
Sci Rep
November 2024
Department of Anatomy, Jinzhou Medical University, Linghe District, Jinzhou, Liaoning, 121001, China.
Article Synopsis
- Researchers used NADPH-d to study neurodegeneration in aged monkeys, building on previous findings in aged rats and dogs.
- They identified two abnormal NADPH-d positive structures: aging-related NADPH-d positive bodies (ANBs) and megaloneurites, primarily found in specific regions of the sacral spinal cord.
- The study concluded that these two alterations serve as potential markers for aging in the pelvic visceral organs of non-human primates, with megaloneurites showing a connection to vasoactive intestinal peptide.
Clinical Anatomy of the Sacral Nerve Roots and Its Relevance to Their Reconstruction After Sacrectomy.
Neurosurgery
August 2024
Center for Endoscopic, Surgical and Clinical Anatomy (CESKA), Second Faculty of Medicine, Charles University, Prague, Czech Republic.
Background And Objectives: En bloc sacrectomy is associated with sacral root transection causing loss of urinary bladder, rectum, and sexual function. The aim of the study was to determine the position of the pudendal branches (sensorimotor) and pelvic splanchnic nerves (parasympathetic) on the sacral roots relative to the sacrum, and the minimal and maximal defects in the sacral roots that can be reconstructed by grafting after various types of sacrectomy.
Methods: Five cadaveric pelves were dissected bilaterally.
Acute Autonomic Nervous System Response to Direct Sacral Nerve Root Stimulation in Lower Urinary Tract Dysfunction: A New Approach to Understand the Mechanism of Action of Sacral Nerve Modulation.
J Urol
August 2024
Department of Urology, Antwerp University Hospital, Edegem, Belgium.
Purpose: Our goal was to assess acute autonomic nervous system (ANS) response to direct sacral nerve root (SNR) stimulation in the context of lower urinary tract dysfunction.
Materials And Methods: In this retrospective monocentric study, patients undergoing 2-stage sacral nerve modulation for overactive bladder, nonobstructive urinary retention, or chronic bladder pain syndrome between March 2022 and June 2023 were analyzed. A standardized stimulation protocol was applied during the lead implantation, each of the 4 contact points being sequentially stimulated at the amplitude required to elicit anal motor response.
Pelvic Neuro-Visualization: An Anatomical Illustration of the Autonomic Pelvic Nervous Network in Gynecologic Surgery.
J Minim Invasive Gynecol
October 2024
Fondazione IRCCS National Cancer Institute of Milan (Ditto, Ferla, Martinelli, Bogani, Maggiore, and Raspagliesi), Milan, Italy.
Objective: During radical pelvic surgeries fibers of the autonomic pelvic nervous network can be accidentally damaged leading to significant visceral sequelae, which dramatically affect women's quality of life because of urinary, anorectal, and sexual postoperative dysfunctions. Direct visualization is one way to preserve hypogastric nerves (HNs), pelvic splanchnic nerves (PSNs), and the bladder branches from the inferior hypogastric plexus (IHP). However, the literature lacks critical photos and/or illustrations that are necessary to understand the precise anatomy needed to preserve the pelvic autonomic fibers.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!