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Objectives: Electroconvulsive therapy (ECT) is frequently associated with significant hemodynamic changes that increase myocardial oxygen demand including significant hypertension poststimulus. This raises concern about the cumulative effect of repetitive stress from ECT. Historically, various agents have been used to blunt this response and reduce hemodynamic fluctuations in these patients with varying degrees of efficacy.

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Article Synopsis
  • Researchers studied how electroconvulsive therapy (ECT) affects the brain and inflammation in people with severe depression who didn't respond to other treatments.
  • They looked at patients' blood for specific chemicals (called cytokines) and used special brain scans to see changes in brain structure before and after ECT.
  • The study found that higher levels of one chemical (IL-8) were linked to positive changes in brain structure in those who responded well to ECT.
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Recent studies examining electroconvulsive therapy (ECT) have reported that early sessions can induce rapid antidepressant and antipsychotic effects, and the early termination of ECT was reported to increase the risk of relapse. We hypothesized that different neural mechanisms associated with the therapeutic effects of ECT may be involved in the different responses observed during the early and late periods of ECT treatment. We investigated whether these antidepressant and antipsychotic effects were associated with temporally and spatially different regional gray matter volume (GMV) changes during ECT.

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