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http://dx.doi.org/10.1111/j.1442-200X.2008.02751.x | DOI Listing |
J Magn Reson Imaging
January 2025
Developing Brain Institute, Children's National Hospital, Washington, D.C., USA.
The biochemical composition and structure of the brain are in a rapid change during the exuberant stage of fetal and neonatal development. H-MRS is a noninvasive tool that can evaluate brain metabolites in healthy fetuses and infants as well as those with neurological diseases. This review aims to provide readers with an understanding of 1) the basic principles and technical considerations relevant to H-MRS in the fetal-neonatal brain and 2) the role of H-MRS in early fetal-neonatal development brain research.
View Article and Find Full Text PDFMedicine (Baltimore)
January 2025
Department of Neonatology, Hangzhou Women's Hospital, Hangzhou, Zhejiang, China.
Rationale: Fetal intestinal volvulus, a rare and severe disorder, poses significant diagnostic challenges prenatally and can lead to intrauterine death or adverse neonatal outcomes if untreated in a timely manner. This study reports a case of fetal intestinal volvulus confirmed postoperatively, providing insights into its clinical manifestations, diagnostic methods, and treatment outcomes, thereby enhancing understanding of this rare condition.
Patient Concerns: A Chinese gravida 2, para 1 female presented at 32 weeks and 5 days of gestation with decreased fetal movements.
Medicine (Baltimore)
January 2025
The Reproductive Medicine Centre, Weifang People's Hospital, Shandong Second Medical University, Weifang, Shandong, China.
Rationale: Microcephaly, epilepsy, and developmental delay (MCSZ) is a rare neurodevelopmental disorder associated with autosomal recessive inheritance of mutations in the polynucleotide kinase 3'-phosphatase (PNKP) gene. Prompt identification and management are essential, as delayed diagnosis or intervention may result in severe complications or mortality. In this case, prenatal screening in the second trimester detected fetal microcephaly with a gradual decline in head circumference, prompting the decision to terminate the pregnancy.
View Article and Find Full Text PDFCommun Biol
January 2025
Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Histological chorioamnionitis (HCA) is a form of maternal immune activation (MIA) linked to an increased risk of neurodevelopmental disorders in offspring. Our previous study identified neurodevelopmental impairments in an MIA mouse model mimicking HCA. Thus, this study investigated the role of CD11c microglia, key contributors to myelination through IGF-1 production, in this pathology.
View Article and Find Full Text PDFPediatr Neurol
December 2024
Department of Radiology, Infocus Diagnostics, Ahmedabad, Gujarat, India.
Background: Thick fetal corpus callosum (CC) is a rare finding and its significance in isolation is not clear. In this retrospective study, we aim to gain insight into the microarchitecture of CC in a cohort of fetuses with thick and short CC (isolated or associated with mild extra-/intracranial abnormalities) as seen on ultrasound (US), by using prenatal magnetic resonance (MR) diffusion tensor imaging (DTI) with fiber tractography, thereby allowing better characterization for postnatal prognosis.
Methods: Twelve fetuses met the inclusion criteria on US.
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