AI Article Synopsis
- The study investigates the impact of sauroine, an alkaloid from Huperzia saururus, on memory and learning in male Wistar rats.
- The research employed both behavioral tests and electrophysiological experiments, particularly the step-down test, to assess memory retention.
- Results indicated that sauroine enhances memory retention and promotes hippocampal plasticity, supporting its traditional medicinal use in Argentina.
Article Abstract
The present study describes the effects of sauroine (1), the main alkaloid obtained from Huperzia saururus, on memory retention and learning. To evaluate this, electrophysiological experiments and behavioral tests (step down) were performed on male Wistar rats. The results showed that 1 improved memory retention in the step-down test, significantly increasing hippocampal plasticity. Thus, 1 seems to be a constituent responsible for the activity claimed in folk medicine for H. saururus in Argentina.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/np800151v | DOI Listing |
Publication Analysis
Top Keywords
memory retention
12
alkaloid huperzia
8
huperzia saururus
8
wistar rats
8
sauroine alkaloid
4
saururus activity
4
activity wistar
4
rats electrophysiological
4
electrophysiological behavioral
4
behavioral assays
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!