Objective: The purpose of this study was to compare the time-course of contrast-enhancement in spleen and liver using Exia 160 in comparison with Fenestra LC and VC in healthy mice.
Procedures: Healthy C57bl/6 mice were used in this study. Fenestra LC and VC was administered intravenously at a dose of 0.1 ml/20 g or 0.2 ml/20 g. Exia 160 at a dose of 0.05 ml/20 g or 0.1 ml/20 g. Each animal underwent a micro-CT scan before contrast injection (baseline) and immediately after contrast injection. Additional scans were performed at 1, 2, 3, 4, 24, and 48 h after contrast administration. The mice who received Exia 160 were also scanned after 15, 30, and 45 min.
Results: The peak enhancement of Exia 160 occurred after 15 min for the spleen and after 30 min for the liver.
Conclusions: Exia 160 allows rapid spleen and liver enhancement. The high iodine content results in small injection volumes.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s11307-008-0186-8 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Contrast-enhanced micro-CT imaging in murine carotid arteries: a new protocol for computing wall shear stress.
Biomed Eng Online
December 2016
Department of Biomedical Engineering, Thorax Center, Erasmus MC, Wytemaweg 80, Ee2338, 3015CN, Rotterdam, The Netherlands.
Background: Wall shear stress (WSS) is involved in the pathophysiology of atherosclerosis. The correlation between WSS and atherosclerosis can be investigated over time using a WSS-manipulated atherosclerotic mouse model. To determine WSS in vivo, detailed 3D geometry of the vessel network is required.
View Article and Find Full Text PDFComparison of small animal CT contrast agents.
Contrast Media Mol Imaging
July 2016
Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tuebingen, Tuebingen, Germany.
Non-invasive in vivo small animal computed tomography (CT) imaging provides high resolution bone scans but cannot differentiate between soft tissues. For most applications injections of contrast agents (CAs) are necessary. Aim of this study was to uncover the advantages and disadvantages of commercially available CT CAs (ExiTron nano 12 000 and 6000, eXIA 160 and 160XL, Fenestra VC and LC) regarding their pharmacokinetics, toxicological side-effects and the influence of anesthesia on the biodistribution, based on an injection volume of 100 μL/25 g body weight.
View Article and Find Full Text PDFTime course of contrast enhancement by micro-CT with dedicated contrast agents in normal mice and mice with hepatocellular carcinoma: comparison of one iodinated and two nanoparticle-based agents.
Acad Radiol
February 2015
Department of Radiology and Nuclear Medicine, Medical School, Otto-von-Guericke University, Magdeburg A.ö.R., Magdeburg, Germany. Electronic address:
Rationale And Objectives: The aim of the present study was to characterize the kinetics of two nanoparticle-based contrast agents for preclinical imaging, Exitron nano 6000 and Exitron nano 12000, and the iodinated agent eXIA 160 in both healthy mice and in a mouse model of hepatocellular carcinoma (HCC). Semiautomatic segmentation of liver lesions for estimation of total tumor load of the liver was evaluated in HCC mice.
Materials And Methods: The normal time course of contrast enhancement was assessed in 15 healthy C57BL/6 mice.
Anatomical and functional imaging of myocardial infarction in mice using micro-CT and eXIA 160 contrast agent.
Contrast Media Mol Imaging
October 2014
Center for In Vivo Microscopy, Department of Radiology, Duke University Medical Center, Durham, NC, 27710, USA.
Noninvasive small animal imaging techniques are essential for evaluation of cardiac disease and potential therapeutics. A novel preclinical iodinated contrast agent called eXIA 160 has recently been developed, which has been evaluated for micro-CT cardiac imaging. eXIA 160 creates strong contrast between blood and tissue immediately after its injection and is subsequently taken up by the myocardium and other metabolically active tissues over time.
View Article and Find Full Text PDFUse of eXIA 160 XL for contrast studies in micro-computed tomography: experimental observations.
Mol Imaging
September 2013
In Vivo Cellular and Molecular Imaging, Vrije Universiteit Brussel, Belgium.
The purpose of this study was to evaluate the time course of contrast enhancement of spleen, liver, and blood using eXIA 160 XL in healthy mice. eXIA 160 XL was intravenously injected in C57bl/6 mice (n = 12) at a dose of 0.1 mL/20 g (16 mg iodine [I]/20 g) (n = 6) or 0.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!