Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
A One Stone Three Birds Paradigm of Photon-Driven Pyroptosis Dye for Amplifying Tumor Immunotherapy.
Adv Sci (Weinh)
January 2025
Department of Chemistry and Nanoscience, Ewha Womans University, Seoul, 03760, South Korea.
Activating the pyroptosis pathway of tumor cells by photodynamic therapy (PDT) for immunogenic cell death (ICD) is considered a valid strategy in pursuit of antitumor immunotherapy, but it remains a huge challenge due to the lack of reliable design guidelines. Moreover, it is often overlooked that conventional PDT can exacerbate the development of tumor immunosuppressive microenvironment, which is apparently unfavorable to clinical immunotherapy. The endoplasmic reticulum's (ER) pivotal role in cellular homeostasis and its emerging link to pyroptosis have galvanized interest in ER-centric imaging and therapeutics.
View Article and Find Full Text PDFCommunity health worker and caregiver experiences and perceptions of a multimodal handheld pulse oximeter used in sick child consultations in rural Burundi: A qualitative evaluation.
PLOS Glob Public Health
January 2025
World Vision Canada, Mississauga, Canada.
Community Health Workers (CHWs) in low- and middle-income countries are essential in providing primary health care to remote communities. However, due to limited diagnostic tools, CHWs often struggle to correctly identify childhood illnesses, especially pneumonia. We conducted a prospective pilot study and used qualitative research methods to evaluate acceptability and feasibility of a multimodal pulse oximeter used by CHWs during their integrated community case management (iCCM) of childhood illness consultations in rural Burundi.
View Article and Find Full Text PDFDialogue mechanisms between astrocytic and neuronal networks: A whole-brain modelling approach.
PLoS Comput Biol
January 2025
Electrical and Computer Engineering Department, Concordia University, Montreal, Canada.
Astrocytes critically shape whole-brain structure and function by forming extensive gap junctional networks that intimately and actively interact with neurons. Despite their importance, existing computational models of whole-brain activity ignore the roles of astrocytes while primarily focusing on neurons. Addressing this oversight, we introduce a biophysical neural mass network model, designed to capture the dynamic interplay between astrocytes and neurons via glutamatergic and GABAergic transmission pathways.
View Article and Find Full Text PDFIntestinal interstitial fluid isolation provides novel insight into the human host-microbiome interface.
Cardiovasc Res
January 2025
Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
Aims: The gastrointestinal (GI) tract is composed of distinct sub-regions, which exhibit segment-specific differences in microbial colonization and (patho)physiological characteristics. Gut microbes can be collectively considered as an active endocrine organ. Microbes produce metabolites, which can be taken up by the host and can actively communicate with the immune cells in the gut lamina propria with consequences for cardiovascular health.
View Article and Find Full Text PDFPresumed bilateral acute idiopathic maculopathy in a pediatric patient.
Am J Ophthalmol Case Rep
March 2025
Department of Ophthalmology, Stanley M. Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, NE, USA.
Purpose: To describe a rare case of presumed bilateral acute idiopathic maculopathy (AIM) in a pediatric patient.
Observation: An 11-year-old male was evaluated for a "fuzzy Dorito-shaped" spot in the central vision of his right eye (OD) that started 3 days before presenting to our clinic. On examination, best-corrected visual acuity (BCVA) was counting fingers at 5 feet OD, and 20/25 in the left eye (OS).
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!