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Antibacterial alkoxybenzamide inhibitors of the essential bacterial cell division protein FtsZ. | LitMetric
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Antibacterial alkoxybenzamide inhibitors of the essential bacterial cell division protein FtsZ.

Lloyd G Czaplewski Ian Collins E Andrew Boyd David Brown Stephen P East Mihaly Gardiner Rowena Fletcher David J Haydon Vincent Henstock Peter Ingram Clare Jones Caterina Noula Leanne Kennison Chris Rockley Valerie Rose Helena B Thomaides-Brears Rebecca Ure Mark Whittaker Neil R Stokes

Bioorg Med Chem Lett

Prolysis Ltd, Begbroke Science Park, Sandy Lane, Yarnton, Oxfordshire OX5 1PF, UK.

Published: January 2009

3-Methoxybenzamide is a weak inhibitor of the essential bacterial cell division protein FtsZ. Exploration of the structure-activity relationships of 3-methoxybenzamide analogues led to the identification of potent anti-staphylococcal compounds.

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 Source
http://dx.doi.org/10.1016/j.bmcl.2008.11.021DOI Listing

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