Novel near-infrared pyrimidine-fused pH fluorescent probes were prepared by an unusual barbiturate-mediated debenzoindolation and subsequent heteroannulation. A plausible mechanistic pathway is proposed, and the final structures were further elucidated by 2D-NMR. All new compounds are highly fluorescent in the near-infrared region and possess excellent spectral sensitivities to environmental pH changes.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725187 | PMC |
| http://dx.doi.org/10.1021/ol802363x | DOI Listing |
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