The novel signal peptide SLPmod was used for the secretion of murine interleukin-12 (mIL-12) by Lactococcus lactis. A >4-fold increase in secretion was observed when SLPmod was used instead of the Usp45-derived secretion signal. Oral delivery of this cytokine using the autoinducible host L. lactis FI5876 utilizing SLPmod resulted in a significant increase in mIL-12 plasma levels in mice.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2632150 | PMC |
| http://dx.doi.org/10.1128/AEM.01728-08 | DOI Listing |
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