Objectives: The performance of encapsulated anterior GI restoratives were compared with their hand-mixed equivalents for the range of powder to liquid mixing ratios routinely encountered clinically. The clinically induced variability of powder to liquid mixing variations of an anhydrous GI restorative formulation was also compared with conventional GI restorative formulations that contained a polyalkenoic acidic liquid.
Methods: Mean compressive fracture strengths, mean elastic moduli and mean total volumetric wear were determined for the encapsulated anterior GI restoratives mechanically mixed in a Capmix or Rotomix machine and the hand-mixed GI restoratives prepared with powder contents reduced from that recommended by the manufacturer (100%) in 10% increments to 50% for a constant weight of liquid. Multiple comparisons of the group means were made using a one-way analysis of variance (ANOVA) and Tukey's multiple range tests employed at P<0.05.
Results: For the encapsulated GI restoratives, the mean compressive fracture strength, mean elastic modulus and in-vitro wear resistance were significantly increased compared with their hand-mixed equivalents prepared with powder contents below that recommended by the manufacturers. The conventional GI restoratives resulted in a linear deterioration (R2>0.95) of the mean compressive fracture strength and mean elastic modulus with powder content compared with the bi-modal deterioration for the anhydrous GI restorative.
Conclusions: Encapsulated anterior GI restoratives outperform their hand-mixed equivalents for the range of powder to liquid mixing ratios routinely encountered clinically such that they are advocated for use in clinical practice. Anhydrous GI restorative formulations are more susceptible to clinically induced variability on mixing compared with conventional GI restorative formulations that contained a polyalkenoic acidic liquid.
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http://dx.doi.org/10.1016/j.jdent.2008.10.006 | DOI Listing |
Eur J Pharm Sci
January 2025
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, 76107, USA; North Texas Eye Research Institute, University of North Texas Health Science Center, Fort Worth, TX, 76107, USA. Electronic address:
Elevated intraocular pressure (IOP) is implicated in the structural and functional damage to the retinal ganglion cells (RGCs) in primary open-angle glaucoma (POAG). Topical IOP lowering agents provide short-term relief, necessitating frequent dosing. Moreover, non-adherence to frequent eyedrops administration contributes significantly to visual field loss and worsens the disease outcome.
View Article and Find Full Text PDFComput Biol Med
December 2024
Department of Applied Mechanics and Biomedical Engineering, Indian Institute of Technology Madras, Chennai, 600036, Tamil Nadu, India. Electronic address:
Background And Objective: Cerebral aneurysms occur as balloon-like outpouchings in an artery, which commonly develop at the weak curved regions and bifurcations. When aneurysms are detected, understanding the risk of rupture is of immense clinical value for better patient management. Towards this, Fluid-Structure Interaction (FSI) studies can improve our understanding of the mechanics behind aneurysm initiation, progression, and rupture.
View Article and Find Full Text PDFAm J Case Rep
December 2024
Department of Anatomical Pathology, Al Borg Medical Laboratories Center, Doha, Qatar.
Rev Esp Cir Ortop Traumatol
December 2024
Servicio de Cirugía Ortopédica y Traumatología, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain; Universidad de Alcalá de Henares, Madrid, Spain.
Objective: To evaluate with an animal model of osteoarthritis (New Zealand rabbits) the effectiveness of treatment with active viscosupplements (hyaluronic acid loaded with nanoparticles (NPs) that encapsulate anti-inflammatory compounds or drugs.
Material And Methods: Experimental study composed of 5 groups of rabbits in which section of the anterior cruciate ligament and resection of the internal meniscus were performed to trigger degenerative changes and use it as a model of osteoarthritis. The groups were divided into osteoarthrosis without treatment (I), treatment with commercial hyaluronic acid (HA) (II), treatment with HA with empty nanoparticles (III), treatment with HA with nanoparticles encapsulating dexamethasone (IV) and treatment with HA with nanoparticles that encapsulate curcumin (V).
Ophthalmic Res
December 2024
Department of Ophthalmology, Pusan National University School of Medicine, Busan, Republic of Korea.
Introduction: Intrableb structures are hallmark features of the filtering bleb. This study aimed to compare the characteristics of functioning blebs using anterior segment optical coherence tomography (AS-OCT) according to amniotic membrane transplantation (AMT).
Methods: Forty eyes from 40 patients diagnosed with primary open-angle glaucoma who underwent trabeculectomy, either with AMT (20 eyes) or without AMT (control group, 20 eyes), were included.
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