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What does a Trump presidency mean for maternal and infant health in Africa?
Afr J Reprod Health
December 2024
Department of Epidemiology and Population Health, School of Public Health & Information Sciences, University of Louisville, Louisville, Kentucky, USA.
It is sometimes said that when America sneezes, the world catches a cold. The opposite scenario may also apply: a healthy and progressive American economy and democracy provides needed resources and hope to many parts of the world, including Africa. Four years ago, we wrote an optimistic message in this journal.
View Article and Find Full Text PDFShort-term outcomes of robot-assisted versus conventional minimally invasive esophagectomy: A propensity score-matched study via a nationwide database.
Ann Gastroenterol Surg
January 2025
The Japan Society for Endoscopic Surgery Tokyo Japan.
Background: The advantages of robot-assisted minimally invasive esophagectomy (RA-MIE) over conventional minimally invasive esophagectomy (C-MIE) are unknown. This nationwide large-scale study aimed to compare surgical outcomes between RA-MIE and C-MIE using rigorous propensity score methods, including detailed covariates and relevant outcomes.
Methods: This Japanese nationwide retrospective cohort study included RA-MIE or C-MIE for esophageal malignant tumors performed between October 2018 and December 2019 and registered in the Japanese National Clinical Database.
Antibiotic prescribing patterns at outpatient clinics in Western and Coastal Kenya.
PLOS Glob Public Health
January 2025
Department of Pediatrics, Division of Pediatric Infectious Diseases, Stanford University School of Medicine, Stanford, California, United States of America.
Antimicrobial resistant pathogens are a leading cause of morbidity and mortality worldwide, with overuse and misuse of antimicrobials being key contributors. We aimed to identify factors associated with antibiotic prescriptions among patients presenting to clinics in Kenya. We performed a retrospective, descriptive cohort study of persons presenting to outpatient clinics in Western and Coastal Kenya, including symptoms, physical exams, clinician assessments, laboratory results and prescriptions.
View Article and Find Full Text PDFLongitudinal phosphoproteomics reveals the PI3K-PAK1 axis as a potential target for recurrent colorectal liver metastases.
Cell Rep
December 2024
Laboratory of Proteomics for Drug Discovery, Center for Drug Design Research, National Institute of Biomedical Innovation, Health and Nutrition, Osaka 567-0085, Japan; Laboratory of Proteomics and Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan. Electronic address:
The resistance of colorectal cancer liver metastases (CRLMs) to 5-fluorouracil (5-FU) chemotherapy remains a significant global health challenge. We investigated the phosphoproteomic dynamics of serial tissue sections obtained from initial metastases and recurrent tumors collected from 24 patients to address this unmet need for innovative therapeutic strategies for patients with CRLM with a poor prognosis. Our analysis revealed the activation of PAK kinase in patients with CRLM with a poor prognosis.
View Article and Find Full Text PDFGrowth retardation and adult height in pediatric patients with chronic-phase chronic myeloid leukemia treated with tyrosine kinase inhibitors.
Leukemia
December 2024
Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan.
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