This seminar provides an overview of chronic angina pectoris. First, the differential diagnosis of chronic angina pectoris is described. The basic pathophysiology of effort angina, including coronary flow physiology as well as the factors that contribute to supply-demand mismatch are discussed. The authors review the published trials that provide the evidence on which angina therapies are based, identifying those treatments that prevent myocardial infarction and death and those that reduce symptoms and ischemia. Newer and investigational agents which can potentially benefit patients with refractory angina are presented. Finally, non-pharmacologic interventions for chronic angina are reviewed.
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