Model selection in kernel linear discriminant analysis (KLDA) refers to the selection of appropriate parameters of a kernel function and the regularizer. By following the principle of maximum information preservation, this paper formulates the model selection problem as a problem of selecting an optimal kernel-induced space in which different classes are maximally separated from each other. A scatter-matrix-based criterion is developed to measure the "goodness" of a kernel-induced space, and the kernel parameters are tuned by maximizing this criterion. This criterion is computationally efficient and is differentiable with respect to the kernel parameters. Compared with the leave-one-out (LOO) or k-fold cross validation (CV), the proposed approach can achieve a faster model selection, especially when the number of training samples is large or when many kernel parameters need to be tuned. To tune the regularization parameter in the KLDA, our criterion is used together with the method proposed by Saadi (2004). Experiments on benchmark data sets verify the effectiveness of this model selection approach.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1109/TNN.2008.2005140 | DOI Listing |
JAMA Netw Open
January 2025
Department of Neurosurgery and Brain Metastasis Center, Memorial Sloan Kettering Cancer Center, New York, New York.
Importance: Approximately one-third of patients with ERBB2 (formerly HER2 or HER2/neu)-positive (ERBB2+) metastatic breast cancer (MBC) develop brain metastasis. It is unclear whether patients with disease limited to the central nervous system (CNS) have different outcomes and causes of death compared with those with concomitant extracranial metastasis.
Objective: To assess overall survival (OS) and CNS-related mortality among patients with ERBB2+ breast cancer and a diagnosis of CNS disease by disease distribution (CNS only vs CNS plus extracranial metastasis).
Crit Care Explor
February 2025
Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom.
Objectives: Sepsis is a life-threatening medical emergency, with a profound healthcare burden globally. Its pathophysiology is complex, heterogeneous and temporally dynamic, making diagnosis challenging. Medical management is predicated on early diagnosis and timely intervention.
View Article and Find Full Text PDFUltrasound Obstet Gynecol
January 2025
Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, Italy.
Objective: Although artificial intelligence (AI) is increasingly being applied to ultrasound imaging in gynecology, efforts to synthesize the available evidence have been inadequate. The aim of this systematic review was to summarize and evaluate the literature on the role of AI applied to ultrasound imaging in benign gynecological disorders.
Methods: Web of Science, PubMed and Scopus databases were searched from inception until August 2024.
Stem Cell Rev Rep
January 2025
Dipartimento di Medicina Sperimentale, Università di Genova, Viale Benedetto XV, 3, Genova, 16132, Italy.
Progress of human brain in vitro models stands as a keystone in neurological and psychiatric research, addressing the limitations posed by species-specific differences in animal models. The generation of human neurons from induced pluripotent stem cells (iPSCs) using transcription factor reprogramming protocols has been shown to reduce heterogeneity and improve consistency across different stem cell lines. Despite notable advancements, the current protocols still exhibit several shortcomings.
View Article and Find Full Text PDFPrev Sci
January 2025
Faculty of Nursing, Physiotherapy, and Podiatry, Department of Nursing, Universidad de Sevilla, Avenzoar Street, 6, 41009, Seville, Spain.
Adolescence is a critical period for developing risk behaviors such as substance use, which can impact health in adulthood. Culturally adapted evidence-based programs (EBPs) are promising for prevention. This review explores the processes for culturally adapting EBPs targeting alcohol, tobacco, or cannabis use, and/or anxiety or depression in adolescents.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!