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Antibacterial neurymenolides from the Fijian red alga Neurymenia fraxinifolia. | LitMetric
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Antibacterial neurymenolides from the Fijian red alga Neurymenia fraxinifolia.

E Paige Stout Adam P Hasemeyer Amy L Lane Theresa M Davenport Sebastian Engel Mark E Hay Craig R Fairchild Jacques Prudhomme Karine Le Roch William Aalbersberg Julia Kubanek

Org Lett

School of Chemistry & Biochemistry, Georgia Institute of Technology, Atlanta, Georgia, 30332, USA.

Published: January 2009

Two novel alpha-pyrone macrolides, neurymenolides A (1) and B (2), were isolated from the Fijian red alga Neurymenia fraxinifolia and characterized using a combination of NMR and mass spectral analyses. These molecules represent only the second example of alpha-pyrone macrolides, with 1 existing as interchanging atropisomers due to restricted rotation about the alpha-pyrone ring system. Neurymenolide A (1) displayed moderately potent activities against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VREF).

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 Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646105PMC
http://dx.doi.org/10.1021/ol8024814DOI Listing

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