Discussions of the efficacy and toxicity of over-the-counter cough and cold medication have been circulating in the pediatric literature for years. Adverse effects of these medications and the lack of evidence of their efficacy in children make their use a serious matter. An additional consideration for physicians is the recreational use of over-the-counter medications, including adolescent abuse of dextromethorphan. The recent increase in media attention to these issues warrants further review.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Accelerating antiviral drug discovery: early hazard detection with a dual zebrafish and cell culture screen of a 403 compound library.
Arch Toxicol
December 2024
Department of Environmental and Molecular Toxicology, Sinnhuber Aquatic Research Laboratory, Oregon State University, Corvallis, OR, 97333, USA.
The constant emergence of new viral pathogens underscores the need for continually evolving, effective antiviral drugs. A key challenge is identifying compounds that are both efficacious and safe, as many candidates fail during development due to unforeseen toxicity. To address this, the embryonic zebrafish morphology, mortality, and behavior (ZBE) screen and the SYSTEMETRIC® Cell Health Screen (CHS) were employed to evaluate the safety of 403 compounds from the Cayman Antiviral Screening Library.
View Article and Find Full Text PDFAn In Vitro Strategy to Evaluate Ketoprofen Phototoxicity at the Molecular and Cellular Levels.
Int J Mol Sci
November 2024
Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, 40-055 Katowice, Poland.
Article Synopsis
- Phototoxicity, a common issue linked to many medications including over-the-counter ones, highlights the importance of testing drugs for their potential to cause harm under UV light!
- This study focuses on the effects of ketoprofen on human skin cells, using various tests to analyze its cytotoxicity and phototoxicity under different treatment conditions!
- Findings revealed that ketoprofen poses the highest risk of phototoxic reactions when it is directly applied to cells during UV exposure, affecting both pigmented and non-pigmented skin cells!
Meclizine seasickness medication and its effect on central nervous system oxygen toxicity in a murine model.
Diving Hyperb Med
December 2024
Motion Sickness and Human Performance Laboratory, The Israel Naval Medical Institute, IDF Medical Corps, Haifa, Israel.
Introduction: Diving utilising closed circuit pure oxygen rebreather systems has become popular in professional settings. One of the hazards the oxygen diver faces is central nervous system oxygen toxicity (CNS-OT), causing potentially fatal convulsions. At the same time, divers frequently travel by boat, often suffering seasickness.
View Article and Find Full Text PDFTUDCA modulates drug bioavailability to regulate resistance to acute ER stress in .
Mol Biol Cell
December 2024
Department of Anatomy and Cell Biology, The University of Western Ontario, London, Ontario, Canada, N6A 5C1.
Cells counter accumulation of misfolded secretory proteins in the endoplasmic reticulum (ER) through activation of the Unfolded Protein Response (UPR). Small molecules termed chemical chaperones can promote protein folding to alleviate ER stress. The bile acid tauroursodeoxycholic acid (TUDCA), has been described as a chemical chaperone.
View Article and Find Full Text PDFFormulation of nasal analgesic sprays with diclofenac sodium, ibuprofen, paracetamol, and evaluation of toxicity.
Sci Prog
December 2024
Department of Otorhinolaryngology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey.
Objective: Intranasal analgesic sprays represent a safe, efficacious method for pain relief, with a shorter working time compared to oral painkillers. This study aimed to develop nasal sprays using commonly available over-the-counter analgesics, providing an alternative treatment option that is more convenient and potentially more effective in managing pain, particularly in pediatric patients.
Methods: Three different nasal spray formulations with the contents of diclofenac sodium, ibuprofen, and paracetamol were created, and characterization studies were completed.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!