The central dogma female reproductive biology has that oogenesis ceases around birth in mammals and human. The ovarian reserve of oocytes is definitely fixed and will deplete up to the menopause in women. The papers by Johnson et al. and Bukovsky et al. overturn this dogma since they claim that female mice and women produce new oocytes during adult life. In conclusion, these observations need to be confirmed by others, they could be considered to question the dogma of fixed stock of oocytes at birth.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Ovarian Stem Cells for Women's Infertility: State of the Art.
Biomedicines
May 2024
FERTILITA Sp. z o.o., 41-700 Ruda Śląska, Poland.
Today, women's infertility is considered a social disease in females, occurring not only as an effect of POF (premature ovarian failure) but also as CTRI (cancer treatment-related infertility) in oncologic patients. Several procedures for FP (fertility preservation) are currently adopted to prevent this condition, mostly based on utilization of retrieved eggs from the patients with subsequent IVF (in vitro fertilization) or cryopreservation. However, great interest has recently been devoted to OSCs (ovarian stem cells), whose isolation from female ovaries, followed by their in vitro culture, led to their maturation to OLCs (oocyte-like cells), namely, neo-oocytes comparable to viable eggs suitable for IVF.
View Article and Find Full Text PDFFertility Preservation in the Era of Immuno-Oncology: Lights and Shadows.
J Pers Med
April 2024
Gynecologic Oncology Unit, Department of Woman, Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00136 Roma, Italy.
In recent years, immuno-oncology has revolutionized the cancer treatment field by harnessing the immune system's power to counteract cancer cells. While this innovative approach holds great promise for improving cancer outcomes, it also raises important considerations related to fertility and reproductive toxicity. In fact, most young females receiving gonadotoxic anti-cancer treatments undergo iatrogenic ovarian exhaustion, resulting in a permanent illness that precludes the vocation of motherhood as a natural female sexual identity.
View Article and Find Full Text PDFOvary does harbor stem cells - size of the cells matter!
J Ovarian Res
April 2020
Stem Cell Biology Department, ICMR-National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai, 400 012, India.
A recent study published in the journal Nature Communications from Karolinska Institute, Sweden was unable to detect stem cells in adult human ovarian cortex by single-cell RNAseq and by studying cell surface antigen profiles by flow cytometry studies. Their findings are startling since stem cells have been well characterized in the adult mammalian ovary of several species including mouse, rabbit, monkey, sheep, pig and humans. Ovarian stem cells include pluripotent, very small embryonic-like stem cells (VSELs) and slightly bigger ovarian stem cells (OSCs) which are easily visualized in smears obtained by gently scraping the ovary surface.
View Article and Find Full Text PDF[Neo-oogenesis in the adult ovary: What do we know?].
Gynecol Obstet Fertil Senol
May 2019
Service de biologie de la reproduction - CECOS, hôpital Sud, université Rennes 1, CHU Rennes, 16, boulevard de Bulgarie, 35000 Rennes, France; Université Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail)-UMR_S1085, 35000 Rennes, France. Electronic address:
For more than a decade, the existence of ovarian stem cells that can contribute to neo-oogenesis in the adult ovary is reported by some teams, challenging the dogma according to which mammalian females are born with a fixed and non-renewed germinal cell pool. The presence of germinal stem cells with mitotic activity suggests the possibility of potential postnatal oogenesis. These cells have both germ-line and stem cell markers in culture.
View Article and Find Full Text PDFPost-natal oogenesis: a concept for controversy that intensified during the last decade.
Zygote
June 2015
Department of Histology and Embryology,School of Medicine, University of Ankara,Ankara,Turkey.
For decades, scientists have considered that female mammals are born with a lifetime reserve of oocytes in the ovary, irrevocably fated to decline after birth. However, controversy in the matter of the possible presence of oocytes and granulosa cells that originate from stem cells in the adult mammalian ovaries has been expanded. The restricted supply of oocytes in adult female mammals has been disputed in recent years by supporters of neo-oogenesis, who claim that germline stem cells (GSCs) exist in the ovarian surface epithelium (OSE) or the bone marrow (BM).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!