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Mid-infrared spectral analysis has long been recognized as the most accurate noninvasive blood glucose measurement method, yet no practical compact mid-infrared blood glucose sensor has ever passed the accuracy benchmark set by the USA Food and Drug Administration (FDA): to substitute for the finger-pricking glucometers in the market, a new sensor must first show that 95% of their glucose measurements have errors below 15% of these glucometers. Although recent innovative exploitations of the well-established Fourier-transform infrared (FTIR) spectroscopy have reached such FDA accuracy benchmarks, an FTIR spectrometer is too bulky. The advancements of quantum cascade lasers (QCLs) can lead to FTIR spectrometers of reduced size, but compact QCL-based noninvasive blood glucose sensors are not yet available.

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Optical Fiber Displacement Sensors (OFDSs) provide several advantages over conventional sensors, including their compact size, flexibility, and immunity to electromagnetic interference. These features make OFDSs ideal for use in confined spaces, such as turbines, where direct laser access is impossible. A critical aspect of OFDS performance is the geometry of the fiber bundle, which influences key parameters such as sensitivity, range, and dead zones.

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Low-power gas sensors that can be used in IoT (Internet of Things) systems, consumer devices, and point-of-care devices will enable new applications in environmental monitoring and health protection. We fabricated a monolithic chemiresistive gas sensor by integrating a micro-lightplate with a 2D sensing material composed of single-layer graphene and monolayer-thick TiO. Applying ultraviolet (380 nm) light with quantum energy above the TiO bandgap effectively enhanced the sensor responses.

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A CRISPR-Cas and Argonaute-Driven Two-Factor Authentication Strategy for Information Security.

ACS Nano

January 2025

Department of Clinical Laboratory of Sir Run Run Shaw Hospital, College of Biosystems Engineering and Food Science, Zhejiang University School of Medicine, Hangzhou 310058, People's Republic of China.

The escalating growth in computing power and the advent of quantum computing present a critical threat to the security of modern cryptography. Two-factor authentication strategies can effectively resist brute-force attacks to improve the security of access control. Herein, we proposed a two-factor and two-authentication entity strategy based on the trans-cleavage activity of CRISPR-Cas and the "dual-step" sequence-specific cleavage of Argonaute.

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A novel electrochemical detection method utilizing a cost-effective hybrid-modified electrode has been established. A glassy carbon (GC) modified electrode was tested for its ability to measure electrochemical tTG antibody levels, which are essential for diagnosing and monitoring Celiac disease (CD). Tissue transglutaminase protein biomolecules are immobilized on a quantum dots-polypyrrole nanocomposite in the improved electrode.

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